N,N-bis-(2-idrossipropil)benzilamina | 20919-82-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-bis-(2-idrossipropil)benzilamina
• 英文别名: N,N-bis(2-hydroxypropyl)benzylamine；Benzyl-bis-<2-hydroxy-propyl>-amin；N-Benzyl-1,1'-iminodipropan-2-ol；benzyl-bis-(2-hydroxy-propyl)-amine；1,1'-(Benzylimino)dipropan-2-ol；1-[benzyl(2-hydroxypropyl)amino]propan-2-ol
• CAS: 20919-82-8
• 化学式: C₁₃H₂₁NO₂
• 分子量: 223.315
• InChiKey: NPMGKAJEKWZCIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-bis-(2-idrossipropil)benzilamina 在 palladium on activated charcoal 氯化亚砜 、 氢气 、 sodium carbonate 作用下， 以 乙醇 为溶剂， 反应 13.0h， 生成 2,6-dimetil-1-fenilpiperazina (trans)
  参考文献：
  名称：

  Fontanella; Mariani; Depaoli, Farmaco, Edizione Scientifica, 1982, vol. 37, # 6, p. 378 - 386

  摘要：

  DOI：
• 作为产物：
  描述：

  苄胺 、 methyloxirane 反应 0.25h， 以78%的产率得到N,N-bis-(2-idrossipropil)benzilamina
  参考文献：
  名称：

  Fontanella; Mariani; Depaoli, Farmaco, Edizione Scientifica, 1982, vol. 37, # 6, p. 378 - 386

  摘要：

  DOI：

文献信息

• SYNTHESIS OF N-SUBSTITUTED DIISOPROPANOLAMINES, THEIR SEBACATE POLYESTERS AND POLYURETHANE ELASTOMERS
  作者：Jean L. Boivin

  DOI：10.1139/v58-206

  日期：1958.10.1

  Several N-substituted diisopropanolamines were prepared by reacting aqueous solutions of amines with excess propylene oxide at ordinary pressure but higher N-substituted diisopropanolamines had to be prepared in an autoclave at 200 °C. The ionization constants of these bases were measured and recorded as pK_a values. Their infrared absorption spectra gave bands common to all diisopropanolamines mainly at 3.04, 7.14, 7.55, 7.85, 9.45, 10.6, and 11.95 microns. Their condensation with sebacic acid gave the corresponding polyesters, which were soluble in strong acids and had molecular weights of about 1500. The hydroxyl-terminated polyesters were cured with a slight excess of 2,4-tolylene diisocyanate at 100 °C for 2 days to yield elastomers of brittle temperatures in the region of −50 °C.

  通过在常压下，将胺的水溶液与过量的丙烯氧基反应，制备了几种N-取代二异丙醇胺。但是，较高的N-取代二异丙醇胺必须在200°C的高压釜中制备。这些碱的解离常数被测量并记录为pK_a值。它们的红外吸收光谱显示出所有二异丙醇胺共有的频带，主要在3.04、7.14、7.55、7.85、9.45、10.6和11.95微米处。它们与癸二酸的缩聚产物是相应的聚酯，溶解在强酸中，分子量约为1500。羟基终止的聚酯在100°C下与轻微过量的2,4-甲苯二异氰酸酯固化2天，形成具有脆性温度在-50°C左右的弹性体。
• Enantiopure 1,5-Diols from Dynamic Kinetic Asymmetric Transformation. Useful Synthetic Intermediates for the Preparation of Chiral Heterocycles
  作者：Karin Leijondahl、Linnéa Borén、Roland Braun、Jan-E. Bäckvall

  DOI：10.1021/ol800468h

  日期：2008.5.1

  Dynamic kinetic asymmetric transformation (DYKAT) of a series of 1,5-diols has been performed in the presence of Candida antarctica lipase B (CALB), Pseudomonas cepacia lipase II (PS-C II), and ruthenium catalyst 4. The resulting optically pure 1,5-diacetates are useful synthetic intermediates, which was demonstrated by the syntheses of both an enantiopure 2,6-disubstituted piperidine and an enantiopure

  在南极假丝酵母脂肪酶B（CALB），洋葱假单胞菌脂肪酶II（PS-C II）和钌催化剂4的存在下，进行了一系列1,5-二醇的动态动力学不对称转化（DYKAT）。纯的1，5-二乙酸酯是有用的合成中间体，这通过对映纯2，6-二取代哌啶和对映纯3，5-二取代吗啉的合成得到证明。
• Enzyme- and Ruthenium-Catalyzed Dynamic Kinetic Asymmetric Transformation of 1,5-Diols. Application to the Synthesis of (+)-Solenopsin A
  作者：Karin Leijondahl、Linnéa Borén、Roland Braun、Jan-E. Bäckvall

  DOI：10.1021/jo8025109

  日期：2009.3.6

  Dynamic kinetic asymmetric transformation (DYKAT) of 1,5-diols via combined lipase and ruthenium catalysis provides enantiomerically pure diacetates in high diastereoselectivity, which can serve as intermediates in natural product synthesis. This is demonstrated by the synthesis of (+)-Solenopsin A.

  通过组合的脂肪酶和钌催化作用的1,5-二醇动态动力学不对称转化（DYKAT）提供了对映体纯的二乙酸酯，具有高非对映选择性，可以用作天然产物合成的中间体。（+）-Solenopsin A的合成证明了这一点。
• Dynamic Kinetic Resolution of Secondary Diols via Coupled Ruthenium and Enzyme Catalysis
  作者：B. Anders Persson、Fernando F. Huerta、Jan-E. Bäckvall

  DOI：10.1021/jo990447u

  日期：1999.7.1

  Enzymatic acylation of secondary symmetrical diols (as meso/dl mixtures) in combination with ruthenium-catalyzed isomerization of the diol led to efficient dynamic kinetic resolution. In this way, a meso/dl mixture of the diol was transformed to enantiomerically pure (R,R)-diacetate, making efficient use of all the diol material. For some of the flexible substrates, substantial amounts of meso-diacetates

  二级对称二醇的酶促酰化（作为 meso/dl 混合物）与钌催化的二醇异构化相结合，导致有效的动态动力学拆分。通过这种方式，二醇的内消旋/dl 混合物转化为对映异构纯的 (R,R)-二乙酸酯，从而有效利用所有二醇材料。对于一些柔性基材，大量的内消旋二乙酸盐作为副产物形成。结果表明，内消旋产物的主要部分是通过分子内酰基转移途径形成的。
• LUBRICATING OIL ADDITIVE AND LUBRICATING OIL COMPOSITION CONTAINING SAME
  申请人：Adeka Corporation

  公开号：EP1717298A1

  公开（公告）日：2006-11-02

  The present invention provides a lubricating oil additive with excellent cleaning performance which does not include metal components such as calcium or magnesium, and a lubricating oil composition containing the same. The lubricating oil additive according to the present invention is characterized by containing a quaternary ammonium salt having a base number of at least 10 mgKOH/g. Examples of such a quaternary ammonium salt include quaternary ammonium salts obtained by subjecting counter anions in cationic surfactants such as tetraalkylammonium chloride and tetraalkylammonium sulfate to salt-exchange.

  本发明提供了一种不含诸如钙或镁等金属成分的具有优异清洁性能的润滑油添加剂，以及含有该添加剂的润滑油组合物。根据本发明的润滑油添加剂的特点是含有碱基数至少为 10 mgKOH/g 的季铵盐。这种季铵盐的例子包括通过对阳离子表面活性剂（如氯化四烷基铵和硫酸四烷基铵）中的反阴离子进行盐交换而得到的季铵盐。