methyl 7,7-dimethoxyheptanoate | 84201-80-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 7,7-dimethoxyheptanoate
• CAS: 84201-80-9
• 化学式: C₁₀H₂₀O₄
• 分子量: 204.266
• InChiKey: PRFTUWPGVGWACW-UHFFFAOYSA-N

物化性质

• 沸点：
  238.2±30.0 °C(Predicted)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 7,7-dimethoxyheptanoate 在 光气 、 乙酸酐 、 溶剂黄146 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 3.83h， 生成 CyAl-5
  参考文献：
  名称：

  Facile synthesis of monofunctional pentamethine carbocyanine fluorophores

  摘要：

  A high-yield route to symmetric, conjugatable pentamethine carbocyanine dyes with far-red/near infrared (NIR) emission between 650 and 700 nm is reported. The dyes are prepared via condensation of indolium or benz[e]indolium inner salts with an alkyl carboxylic acid derivatized malonaldehyde dianil or alternatively in a one-pot reaction without isolation of the malonaldehyde intermediate. The fluorophores are water-soluble, have bright fluorescence emission, are easily prepared in good yield, and are promising candidates for use in a variety of biochemical and in vivo imaging applications. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2010.12.008
• 作为产物：
  描述：

  环庚烯 在 乙酸酐 、 氢气 、 臭氧 、 三乙胺 作用下， 以 various solvent(s) 为溶剂， 生成 methyl 7,7-dimethoxyheptanoate
  参考文献：
  名称：

  Novel methods for the construction of 3-(2H) Furanone Spiroketals

  摘要：

  Two stereoselective routes to the 3-(2 H) furanone spiroketal 1 have been achieved.

  DOI：

  10.1016/s0040-4039(00)92505-x

文献信息

• Photo-Cleavage of Carbon-Carbon Bond of<b><i>α</i></b>-Iodocycloalkanones Giving<b><i>ω</i></b>,<b><i>ω</i></b>-Dialkoxyalkanoic Ester in Alcohol
  作者：Shun-Jun Ji、C. Akira Horiuchi

  DOI：10.1246/bcsj.73.1645

  日期：2000.7

  The irradiation at λ > 300 nm of α-iodocycloalkanones with a high-pressure mercury lamp in alcohols containing a small amount of water afforded the corresponding ω,ω-dialkoxyalkanoic ester (65—88%) by photochemical cleavage of the C(I)-C=O bond at room temperature. In the case of a commercial fluorescent lamp as the irradiating light source, photochemical ring-opening products were also obtained. The irradiation of 2α-iodo-5α- and 4β-iodo-5β-cholestan-3-ones in methanol gave methyl 2,2-dimethoxy-2,3-seco-5α-cholestan-3-oate and methyl 4,4-dimethoxy-3,4-seco-5β-cholestan-3-oate in 78 and 62% yields, respectively. The photochemical behavior of the cleavage reaction of α-iodocycloalkanones is also discussed on the basis of 2-hydroxycycloalkanone as an intermediate.

  在含有少量水的醇中，用高压汞灯在 λ > 300 纳米波长下照射 α-碘环烷酮，可在室温下通过 C(I)-C=O 键的光化学裂解得到相应的 ω,ω- 二烷氧基烷酸酯（65-88%）。在使用商用荧光灯作为照射光源的情况下，也能获得光化学开环产物。在甲醇中辐照 2α-iodo-5α- 和 4β-iodo-5β-cholestan-3- 酮，可得到 2,2-二甲氧基-2,3-seco-5α-胆甾烷-3-酸甲酯和 4,4-二甲氧基-3,4-seco-5β-胆甾烷-3-酸甲酯，收率分别为 78% 和 62%。此外，还以 2-hydroxycycloalkanone 为中间体，讨论了 α-iodocycloalkanones 裂解反应的光化学行为。
• MONOFUNCTIONAL CARBOCYANINE DYES FOR IN VIVO AND IN VITRO IMAGING
  申请人：Hilderbrand Scott A.

  公开号：US20110286933A1

  公开（公告）日：2011-11-24

  The present invention provides symmetric carbocyanine dyes and dye precursors useful for fluorescence microscopy, and methods of making and using same.

  本发明提供了对称的碳氰染料和染料前体，可用于荧光显微镜技术，并提供制备和使用该染料的方法。
• Monofunctional carbocyanine dyes for in vivo and in vitro imaging
  申请人：Hilderbrand Scott A.

  公开号：US08916137B2

  公开（公告）日：2014-12-23

  The present invention provides symmetric carbocyanine dyes and dye precursors useful for fluorescence microscopy, and methods of making and using same.

  本发明提供了对称的碳氰染料和染料前体，可用于荧光显微镜，以及制备和使用它们的方法。
• A direct conversion of (α-hydroxyalkyl)silanes to carboxylic acids
  作者：Russell J. Linderman、Kangyi Chen

  DOI：10.1016/s0040-4039(00)61771-9

  日期：1992.11

  (alpha-hydroxyalkyl)trialkylsilanes and acylsilanes are readily oxidized to the corresponding carboxylic acid using ozone.
• [EN] MONOFUNCTIONAL CARBOCYANINE DYES FOR IN VIVO AND IN VITRO IMAGING<br/>[FR] COLORANTS MONOFONCTIONNELS À BASE DE CARBOCYANINE POUR IMAGERIE IN VIVO ET IN VITRO
  申请人：GEN HOSPITAL CORP

  公开号：WO2010054330A3

  公开（公告）日：2010-09-30