ethyl 3,3-bis(2,5-dimethylfur-3-yl)propionate | 1159420-81-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 3,3-bis(2,5-dimethylfur-3-yl)propionate
• CAS: 1159420-81-1
• 化学式: C₁₇H₂₂O₄
• 分子量: 290.359
• InChiKey: UUKFOMOFPHFJTR-UHFFFAOYSA-N

物化性质

• 沸点：
  366.2±37.0 °C(predicted)
• 密度：
  1.076±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.19
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  52.58
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2,5-二甲基呋喃 、 丙炔酸乙酯 在 potassium tetrachloroplatinate 、 silver trifluoromethanesulfonate 作用下， 以 溶剂黄146 为溶剂， 反应 40.0h， 以51%的产率得到ethyl 3,3-bis(2,5-dimethylfur-3-yl)propionate
  参考文献：
  名称：

  Pt(II)-catalyzed hydroarylation reaction of alkynes with pyrroles and furans

  摘要：

  A Pt(II) catalyst showed a drastic effect on hydroarylation of alkynes with pyrroles and furans compared with Pd(OAc)(2) catalyst. The hydroarylation reactions proceeded smoothly under mild conditions to double-hydroarylation products in good yields. Mono-adducts Were formed only when the second hydroarylation was inhibited by steric hindrance Of Substrates or low reactivity of the mono-adducts. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.022

文献信息

• Pt(II)-catalyzed hydroarylation reaction of alkynes with pyrroles and furans
  作者：Juzo Oyamada、Tsugio Kitamura

  DOI：10.1016/j.tet.2009.03.022

  日期：2009.5

  A Pt(II) catalyst showed a drastic effect on hydroarylation of alkynes with pyrroles and furans compared with Pd(OAc)(2) catalyst. The hydroarylation reactions proceeded smoothly under mild conditions to double-hydroarylation products in good yields. Mono-adducts Were formed only when the second hydroarylation was inhibited by steric hindrance Of Substrates or low reactivity of the mono-adducts. (C) 2009 Elsevier Ltd. All rights reserved.