N-(6-methoxypyridin-3-yl)methanesulfonamide | 1217028-63-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(6-methoxypyridin-3-yl)methanesulfonamide
• CAS: 1217028-63-1
• 化学式: C₇H₁₀N₂O₃S
• mdl: MFCD14861349
• 分子量: 202.234
• InChiKey: PAUBTVFWYXIFLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲烷磺酰基叠氮化物 、 2-甲氧基-5-吡啶硼酸 在 copper(l) chloride 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以28%的产率得到N-(6-methoxypyridin-3-yl)methanesulfonamide
  参考文献：
  名称：

  10.1021/ol403717

  摘要：

  DOI：

  10.1021/ol403717

文献信息

• PI-kinase Inhibitors with Broad Spectrum Anti-Infective Activity
  申请人：The Regents of the University of California

  公开号：US20150051193A1

  公开（公告）日：2015-02-19

  Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.
• PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20160194314A1

  公开（公告）日：2016-07-07

  Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-hetereoaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.
• US9309236B2
  申请人：——

  公开号：US9309236B2

  公开（公告）日：2016-04-12
• [EN] PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY<br/>[FR] INHIBITEURS DE LA PI-KINASE À ACTIVITÉ ANTI-INFECTIEUSE
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2017147526A1

  公开（公告）日：2017-08-31

  Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-hetereoaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.
• [EN] PI4-KINASE INHIBITORS WITH ANTI-CANCER ACTIVITY<br/>[FR] INHIBITEURS DE LA PI4-KINASE PRÉSENTANT UNE ACTIVITÉ ANTI-CANCÉREUSE
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2020146657A1

  公开（公告）日：2020-07-16

  Methods of treating a subject for cancer using a PI4-kinase inhibitor are provided. Also provided are methods of inhibiting PI4-kinase in a cancer cell to reduce cellular proliferation. The PI4-kinase inhibitor can be a compound that is a 5-aryl or heteroaryl-thiazole, e.g., as described herein. In certain embodiments, the PI4-kinase inhibitor is a substituted 2-amino-5-phenylthiazole or substituted 2-amino-5-pyridylthiazole compound. The subject compounds may be formulated or provided to a subject in combination with one or more additional anti-cancer agents. Use of PI4-kinase inhibitors in methods of reducing cellular proliferation and methods of treatment is provided in a variety of cancer cells and cancer subjects.