3-Deoxy-α,β-DL-ribo-hexopyranose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Deoxy-α,β-DL-ribo-hexopyranose
• 英文别名: 3-Deoxyhexopyranose；6-(hydroxymethyl)oxane-2,3,5-triol
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: RJDIFQMDPPUATQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• FACTOR VIIA INHIBITOR
  申请人：PHARMACYCLICS, INC.

  公开号：US20140080879A1

  公开（公告）日：2014-03-20

  The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

  本发明涉及新型因子VIIa、IXa、Xa、XIa的抑制剂，特别是因子VIIa，包括这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病、癌症或类风湿性关节炎的方法。还公开了制备这些抑制剂的方法。
• [EN] METHOD FOR THE SYNTHESIS OF ASPALATHIN AND ANALOGUES THEREOF<br/>[FR] PROCÉDÉ DE SYNTHÈSE D'ASPALATHINE ET DE SES ANALOGUES
  申请人：SOUTH AFRICAN MEDICAL RES COUNCIL

  公开号：WO2011064726A1

  公开（公告）日：2011-06-03

  A method of synthesising Aspalathin and its analogues or derivatives is disclosed. The method comprises synthesising a compound of formula 1 or its analogues or derivatives (I) wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 is independently selected from the group consisting of -H, -OH, hydrocarbyl groups, saccharide moieties and -OR15; R15 is selected from the group consisting of hydrogen, a hydrocarbyl group (e.g. methoxy or ethoxy), an acyl group and a benzyl group; and R11, R12, R13 and R14 are independently selected from the group consisting of -H, hydrocarbyl groups, saccharide moieties, an acyl group and a benzyl group. The method comprises the step of coupling a sugar to a dihydrochalcone, chalcone or flavanone, or coupling the sugar to an intermediate for producing a dihydrochalcone, chalcone or flavanone followed by coupling of the sugar-intermediate adduct to a further intermediate for producing a dihydrochalcone, chalcone or flavanone, and transforming the product thereof into a compound of formula 1 or an analogue or derivative thereof.

  公开了一种合成Aspalathin及其类似物或衍生物的方法。该方法包括合成式1或其类似物或衍生物（I）的化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10中的每一个都是独立地选自-H、-OH、烃基、糖基和-OR15的群组；R15选自氢、烃基（例如甲氧基或乙氧基）、酰基和苄基的群组；R11、R12、R13和R14独立地选自-H、烃基、糖基、酰基和苄基的群组。该方法包括将糖与二氢黄烷酮、黄烷酮或黄酮偶联，或将糖与产生二氢黄烷酮、黄烷酮或黄酮的中间体偶联，然后将糖-中间体加合物与产生二氢黄烷酮、黄烷酮或黄酮的进一步中间体偶联，并将其产物转化为式1或其类似物或衍生物的化合物。
• 2-(2-Hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
  申请人：Kolesnikov Aleksandr

  公开号：US20060205942A1

  公开（公告）日：2006-09-14

  The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

  本发明涉及新型因子VIIa，IXa，Xa，XIa的抑制剂，尤其是因子VIIa，包含这些抑制剂的制药组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病、癌症或类风湿性关节炎的方法。还公开了制备这些抑制剂的过程。
• 2-(2-Hydroxybiphenyl-3-yl)-1H-Benzoimidazole-5-Carboxamidine Derivatives as Factor VIIA Inhibitors
  申请人：KOLESNIKOV Aleksandr

  公开号：US20090054432A1

  公开（公告）日：2009-02-26

  The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

  本发明涉及新型 VIIa、IXa、Xa、XIa 因子的抑制剂，特别是 VIIa 因子的抑制剂，包括这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病、癌症或类风湿关节炎的方法。本发明还公开了制备这些抑制剂的方法。
• Factor Viia Inhibitor
  申请人：Dickman Daniel A.

  公开号：US20080275250A1

  公开（公告）日：2008-11-06

  The present invention relates to novel inhibitors or Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

  本发明涉及新型抑制剂或因子VIIa、IXa、Xa、XIa，特别是因子VIIa，包括这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病、癌症或类风湿性关节炎的方法。还公开了制备这些抑制剂的工艺。