2-hydroxy-1-phenyl-2-(2-pyridyl)ethanone | 76981-27-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-hydroxy-1-phenyl-2-(2-pyridyl)ethanone
• 英文别名: 2-Hydroxy-1-phenyl-2-[2]pyridyl-aethanon；2-Hydroxy-1-phenyl-2-pyridin-2-ylethanone
• CAS: 76981-27-6
• 化学式: C₁₃H₁₁NO₂
• 分子量: 213.236
• InChiKey: GGMIUTPOOCYGAF-UHFFFAOYSA-N

物化性质

• 沸点：
  375.8±27.0 °C(Predicted)
• 密度：
  1.231±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-phenyl-2-pyridin-2-yl-ethane-1,2-dione 在 甲醇 、 铂 作用下， 生成 2-hydroxy-1-phenyl-2-(2-pyridyl)ethanone
  参考文献：
  名称：

  THE INFLUENCE OF CHELATION ON THE STABILITY OF ENEDIOLS. I. 2-PYRIDOIN, 1-PHENYL-2-(2-PYRIDYL)-1,2-ETHENEDIOL, AND 1-PHENYL-2-(4-PYRIDYL)-1,2-ETHENEDIOL

  摘要：

  DOI：

  10.1021/jo01127a010

文献信息

• Reduction by a Model of NAD(P)H. 28. Reduction of an α-Diketone in the Presence of Zinc Ion
  作者：Atsuyoshi Ohno、Shinro Yasui、Shinzaburo Oka

  DOI：10.1246/bcsj.53.3244

  日期：1980.11

  Reduction of 1-phenyl-2-(2-pyridyl)-1,2-ethanedione with 1-benzyl-1,4-dihydronicotinamide in acetonitrile in the presence of zinc perchlorate has been studied. The α-diketone coordinates onto zinc ion through its pyridine-ring nitrogen and benzene-side carbonyl oxygen, whereas the reduction takes place on pyridine-side carbonyl group. It is concluded that an effective ligand to a metal ion is not necessarily a facile substrate of the reduction.

  研究了 1-苯基-2-(2-吡啶基)-1,2-乙二酮与 1-苄基-1,4-二氢烟酰胺在高氯酸锌存在下于乙腈中的还原反应。α-二酮通过其吡啶环氮和苯侧羰基氧与锌离子配位，而还原作用则发生在吡啶侧羰基上。结论是，对金属离子有效的配体并不一定是易于还原的底物。
• Method for the preparation of symmetrical monoacetals of aromatic 1,2-diketones starting from the corresponding alphahydroxyketones
  申请人：FRATELLI LAMBERTI S.p.A.

  公开号：EP0085031A2

  公开（公告）日：1983-08-03

  The invention relates to a process for the production of symmetrical monoacetals of aromatic 1,2-diketones starting from the corresponding alphahydroxyketones and to their use as photoinitiators of polymerisation by ultraviolet radiations. According to the process of the invention, protection of the carbonyl group is not operated, and the aromatic alphahydroxyketones react, in the first step of the reaction, with an halogenating agent in presence of N-substituted aliphatic amide or an aliphatic alcohol from 1 to 5 atoms and, in the second step, with an alkaline metal alcoholate or an alcohol. If the carbonylic group is protected, the alphahydroxyketones are first converted into acetals or hydrazones and then into the products of the invention by means of oxidation or acetalisation.

  本发明涉及从相应的α-羟基酮开始生产芳香族 1,2-二酮的对称单乙醛的工艺，以及将其用作紫外线聚合的光引发剂。 根据本发明的工艺，不对羰基进行保护，在反应的第一步，芳香族α-羟基酮在 1 至 5 个原子的 N-取代脂肪族酰胺或脂肪族醇存在下与卤化剂反应，在第二步，与碱金属醇酸酯或醇反应。如果羰基受到保护，α-羟基酮首先转化为缩醛或酰肼，然后通过氧化或缩醛化反应转化为本发明的产品。
• THE INFLUENCE OF CHELATION ON THE STABILITY OF ENEDIOLS. I. 2-PYRIDOIN, 1-PHENYL-2-(2-PYRIDYL)-1,2-ETHENEDIOL, AND 1-PHENYL-2-(4-PYRIDYL)-1,2-ETHENEDIOL
  作者：C. A. BUEHLER、JOHN W. ADDLEBURG、DAN M. GLENN

  DOI：10.1021/jo01127a010

  日期：1955.10