6-Methyl-7-phenyl-3H-isobenzofuran-1-one | 234452-22-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 6-Methyl-7-phenyl-3H-isobenzofuran-1-one
• 英文别名: 6-methyl-7-phenyl-3H-2-benzofuran-1-one
• CAS: 234452-22-3
• 化学式: C₁₅H₁₂O₂
• 分子量: 224.259
• InChiKey: DEDGOEWLOGAVSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-Methyl-7-phenyl-3H-isobenzofuran-1-one 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates

  摘要：

  A new prodrug approach for intracellular delivery of phosphonates was developed via the synthesis of 3-phthalidyl esters of 1-naphthalenemethylphosphonate. This approach is advantageous over the traditional acyloxymethyl phosphonate prodrugs, because these prodrugs do not generate formaldehyde and have improved plasma half-lives. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00239-5
• 作为产物：
  描述：

  在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以90%的产率得到6-Methyl-7-phenyl-3H-isobenzofuran-1-one
  参考文献：
  名称：

  Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates

  摘要：

  A new prodrug approach for intracellular delivery of phosphonates was developed via the synthesis of 3-phthalidyl esters of 1-naphthalenemethylphosphonate. This approach is advantageous over the traditional acyloxymethyl phosphonate prodrugs, because these prodrugs do not generate formaldehyde and have improved plasma half-lives. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00239-5

文献信息

• Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates
  作者：Qun Dang、Brian S. Brown、Paul D. van Poelje、Timothy J. Colby、Mark D. Erion

  DOI：10.1016/s0960-894x(99)00239-5

  日期：1999.6

  A new prodrug approach for intracellular delivery of phosphonates was developed via the synthesis of 3-phthalidyl esters of 1-naphthalenemethylphosphonate. This approach is advantageous over the traditional acyloxymethyl phosphonate prodrugs, because these prodrugs do not generate formaldehyde and have improved plasma half-lives. (C) 1999 Elsevier Science Ltd. All rights reserved.