5-[(3E,6E,9E,12E,15E)-1-碘十八碳-3,6,9,12,15-五烯基]四氢呋喃-2-酮 | 78144-19-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 中文名称: 5-[(3E,6E,9E,12E,15E)-1-碘十八碳-3,6,9,12,15-五烯基]四氢呋喃-2-酮
• 英文名称: 5-[(3E,6E,9E,12E,15E)-1-iodooctadeca-3,6,9,12,15-pentaenyl]oxolan-2-one
• CAS: 78144-19-1
• 化学式: C₂₂H₃₁IO₂
• 分子量: 454.4
• InChiKey: JVGLFGABRWZJME-RCHUDCCISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4E,7E,10E,13E,16E,19E)-Docosa-4,7,10,13,16,19-hexaenoic acid 生成 5-[(3E,6E,9E,12E,15E)-1-碘十八碳-3,6,9,12,15-五烯基]四氢呋喃-2-酮
  参考文献：
  名称：

  COREY, E. J.;WRIGHT, STEPHEN W., J. ORG. CHEM., 53,(1988) N 25, C. 5980-5981

  摘要：

  DOI：

文献信息

• COREY, E. J.;WRIGHT, STEPHEN W., J. ORG. CHEM., 53,(1988) N 25, C. 5980-5981
  作者：COREY, E. J.、WRIGHT, STEPHEN W.

  DOI：——

  日期：——
• SYNTHESIS OF RESOLVINS AND INTERMEDIATES, COMPOUNDS PREPARED THEREBY, AND USES THEREOF
  申请人：Rodriguez Ana

  公开号：US20100159540A1

  公开（公告）日：2010-06-24

  Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ω-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.