5-bromo-3-hydroxy-3-[2-(3-nitrophenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one | 258264-63-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-bromo-3-hydroxy-3-[2-(3-nitrophenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one
• 英文别名: 5-bromo-3-hydroxy-3-[2-(3-nitrophenyl)-2-oxoethyl]-1H-indol-2-one
• CAS: 258264-63-0
• 化学式: C16H11BrN2O5
• 分子量: 391.17
• InChiKey: XWXHRRJHPBWPLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR<br/>[FR] PROCÉDÉ DE TRAITEMENT D'UN CANCER À L'AIDE D'UN INHIBITEUR DE SURVIVINE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2010083505A1

  公开（公告）日：2010-07-22

  Disclosed herein are methods of treating cancer by administering to a patient a small molecule inhibitor of Survivin. Also disclosed herein are methods of inhibiting Survivin dimerization in a patient by administering a compound of formula (I), (II), (III), or (IV). Methods of inducing cell cycle arrest in cancer cells, comprising G2/M stage arrest, in a patient by administering a compound of formula (I), (II), (III), or (IV) are also disclosed. Further disclosed herein are methods of inducing apoptosis in cancer cells in a patient by administering a compound of formula (I), (II), (III), or (IV).