1-[4-[3-(4-Nitrophenyl)sulfonyl-2-phenyl-1,3-oxazolidin-4-yl]phenyl]ethanone | 1253298-01-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-[3-(4-Nitrophenyl)sulfonyl-2-phenyl-1,3-oxazolidin-4-yl]phenyl]ethanone
• CAS: 1253298-01-9
• 化学式: C₂₃H₂₀N₂O₆S
• 分子量: 452.488
• InChiKey: DTWWMOHGYHOUPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-(4-乙烯基-苯基)-乙酮 、 2-((4-nitrophenyl)sulfonyl)-3-phenyl-1,2-oxaziridine 在 四丁基氯化铵 、 copper dichloride 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以59%的产率得到1-[4-[3-(4-Nitrophenyl)sulfonyl-2-phenyl-1,3-oxazolidin-4-yl]phenyl]ethanone
  参考文献：
  名称：

  N-Nosyl oxaziridines as terminal oxidants in copper(II)-catalyzed olefin oxyaminations

  摘要：

  We report that N-4-nosyl-3-phenyloxaziridine is an effective terminal oxidant for copper(II)-catalyzed oxyamination recently developed in our labs. This oxaziridine can be prepared on multi-gram scale and is easily purified by recrystallization. The products of oxyamination using this oxaziridine bear protecting groups that can be readily removed in high yields under mild conditions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.015

文献信息

• N-Nosyl oxaziridines as terminal oxidants in copper(II)-catalyzed olefin oxyaminations
  作者：Sandra M. DePorter、Ashley C. Jacobsen、Katherine M. Partridge、Kevin S. Williamson、Tehshik P. Yoon

  DOI：10.1016/j.tetlet.2010.08.015

  日期：2010.10

  We report that N-4-nosyl-3-phenyloxaziridine is an effective terminal oxidant for copper(II)-catalyzed oxyamination recently developed in our labs. This oxaziridine can be prepared on multi-gram scale and is easily purified by recrystallization. The products of oxyamination using this oxaziridine bear protecting groups that can be readily removed in high yields under mild conditions. (C) 2010 Elsevier Ltd. All rights reserved.