17,18-DiHETE | 1027102-05-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 17,18-DiHETE
• 英文别名: (5Z,8Z,11Z,14Z)-17,18-dihydroxyicosa-5,8,11,14-tetraenoic acid
• CAS: 1027102-05-1
• 化学式: C₂₀H₃₂O₄
• 分子量: 336.472
• InChiKey: XYDVGNAQQFWZEF-JPURVOHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  17,18-DiHETE 在 4-二甲氨基吡啶 、 三乙胺 作用下， 生成 (5Z,8Z,11Z,14Z)-17,18-Bis-trimethylsilanyloxy-icosa-5,8,11,14-tetraenoic acid methyl ester
  参考文献：
  名称：

  Selective terminal olefin oxidation of n-3 polyunsaturated fatty acids

  摘要：

  Through the action of N-bromosuccinimide in aqueous glyme, terminal double bond of n-3 fatty acids was selectively converted to the corresponding bromohydrin. This evidence suggests the tight conformation of the n-3 fatty acids in aqueous medium.

  DOI：

  10.1016/s0040-4039(00)91651-4
• 作为产物：
  描述：

  ()17(18)-EpETE methyl ester 在 氢氧化钾 、 sodium acetate 、 溶剂黄146 作用下， 生成 17,18-DiHETE
  参考文献：
  名称：

  Selective terminal olefin oxidation of n-3 polyunsaturated fatty acids

  摘要：

  Through the action of N-bromosuccinimide in aqueous glyme, terminal double bond of n-3 fatty acids was selectively converted to the corresponding bromohydrin. This evidence suggests the tight conformation of the n-3 fatty acids in aqueous medium.

  DOI：

  10.1016/s0040-4039(00)91651-4

文献信息

• BIOMARKERS FOR DETECTION OF CORONARY ARTERY DISEASE AND ITS MANAGEMENT
  申请人：Oregon State University

  公开号：US20210223269A1

  公开（公告）日：2021-07-22

  The present disclosure provides biomarkers for the detection of coronary artery disease. The biomarkers comprise oxylipins and the detection, identification, and quantification can provide a means to diagnose, prognose, and manage subject at risk for cardiovascular disease. Methods of also provided for the detection and quantification of the oxylipins, for treating, and for predicting the survival of a subject at high risk for coronary artery disease.