2-(3-Methylpyridin-1-ium-1-yl)-1-thiophen-2-ylethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(3-Methylpyridin-1-ium-1-yl)-1-thiophen-2-ylethanone
• 化学式: C12H12NOS+
• 分子量: 218.3
• InChiKey: UTIUKXVEFBBJNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  49.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof
  申请人：Sankaranarayanan Alangudi

  公开号：US20070167493A1

  公开（公告）日：2007-07-19

  The invention discloses a new clause of a five membered heterocylic ring compounds of general formula I and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specification. The invention also discloses a process for preparation of these compound and their therapeutic and cosmetic applications particularly in the management of aging related and diabetic vascular complications. The compounds in question act by triple action of an AGE (Advanced Glycation Endproducts) breaker, AGE inhibitor and free radical scavenger which make them most suitable in different therapeutic and cosmetic applications. The invention also discloses pharmaceuticals and cosmetic compositions comprising these compounds and method of treatment of diseases caused by accumulation of AGE and/or free radicals in the body cells.

  本发明公开了一种新的五元杂环环化合物的条款，其通式为I，并且其药学或化妆品上可接受的盐，其中R1，R2，R3，R4，R5，A，B，X和Y如规范中所定义。该发明还公开了这些化合物的制备过程以及它们在治疗衰老相关和糖尿病血管并发症方面的治疗和化妆品应用。所述化合物通过AGE（高级糖基化终产物）破坏剂、AGE抑制剂和自由基清除剂的三重作用来发挥作用，使它们在不同的治疗和化妆品应用中最适用。该发明还公开了包含这些化合物的药物和化妆品组合物以及通过清除体内细胞中AGE和/或自由基积累引起的疾病的治疗方法。