2-O-Sulfo-Alpha-L-Idopyranuronic Acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-O-Sulfo-Alpha-L-Idopyranuronic Acid
• 英文别名: (2R,3S,4S,5R,6R)-3,4,6-trihydroxy-5-sulfooxyoxane-2-carboxylic acid
• 化学式: C₆H₁₀O₁₀S
• 分子量: 274.2
• InChiKey: COJBCAMFZDFGFK-VCSGLWQLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  179
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• COMPOSITION CONSISTING OF HEPARIN FRACTIONS HAVING REPRODUCIBLE CHARACTERISTICS WITH AVERAGE MOLECULAR WEIGHT EQUAL TO 5200D
  申请人：——

  公开号：US20020010152A1

  公开（公告）日：2002-01-24

  Composition consisting of heparin fractions having reproducible characteristics with average molecular weight of 5,200 D obtained by depolymerization with gamma radiation and subsequent fractionation by gel permeation, having high antithrombotic properties and particularly suitable for the prophilaxis and the therapy of the alterations of the plasmatic homeostasis.

  由平均分子量为 5,200 D 的肝素馏分组成的复方制剂，具有可重复的特性，通过伽马射线解聚，然后用凝胶渗透法分馏获得，具有很高的抗血栓性能，特别适用于预防血栓形成和治疗血浆稳态的改变。
• TRANSMUCOSAL DELIVERY SYSTEM
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0804154A1

  公开（公告）日：1997-11-05
• IMPROVED PROCESS FOR THE PREPARATION OF DALTEPARIN SODIUM
  申请人：Biological E Limited

  公开号：EP3740513A1

  公开（公告）日：2020-11-25
• METHODS FOR SYNTHESIZING ANTICOAGULANT POLYSACCHARIDES
  申请人：Optimvia, LLC

  公开号：EP3997238A1

  公开（公告）日：2022-05-18
• GENE THERAPY FOR TREATING MUCOPOLYSACCHARIDOSIS TYPE II
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20200246439A1

  公开（公告）日：2020-08-06

  A co-therapeutic regimen comprising AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDS gene and two or more immunosuppressants is provided herein. Also provided are methods and kits containing these vectors and compositions useful for treating Hunter syndrome and the symptoms associated with Hunter syndrome.