beta-Garosamine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: beta-Garosamine
• 英文别名: (2S,3R,4R,5R)-5-methyl-4-(methylamino)oxane-2,3,5-triol
• 化学式: C₇H₁₅NO₄
• 分子量: 177.2
• InChiKey: VXWORWYFOFDZLY-JWXFUTCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  82
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
  申请人：Achaogen, Inc.

  公开号：EP3150617A1

  公开（公告）日：2017-04-05

  Compounds of structure (I): having antibacterial activity are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本发明公开了具有抗菌活性的结构(I)化合物，包括其立体异构体、药学上可接受的盐和原药，其中 Q1、Q2、Q3、R8 和 R9 如本文所定义。还公开了与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。
• US4049498A
  申请人：——

  公开号：US4049498A

  公开（公告）日：1977-09-20
• [EN] AMINOGLYCOSIDE DOSING REGIMENS<br/>[FR] SCHÉMAS POSOLOGIQUES D'AMINOGLYCOSIDE
  申请人：ACHAOGEN INC

  公开号：WO2010132839A2

  公开（公告）日：2010-11-18

  The present invention provides new aminoglycoside dosing regimens associated with enhanced microbicidal activity and reduced nephrotoxicity, as well as methods of using these dosing regimens to treat various bacterial infections.
• [EN] ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS<br/>[FR] ANALOGUES D'AMINOGLYCOSIDE ANTIBACTÉRIENS
  申请人：ACHAOGEN INC

  公开号：WO2010132765A2

  公开（公告）日：2010-11-18

  Antibacterial compounds of structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2, R3, R11 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
• [EN] COMBINATION THERAPIES USING ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS<br/>[FR] THERAPIE DE COMBINAISON METTANT EN OEUVRE DES COMPOSES D'AMINOGLYCOSIDE ANTIBACTERIENS
  申请人：ACHAOGEN INC

  公开号：WO2010147836A1

  公开（公告）日：2010-12-23

  Methods for treating a bacterial infection in a mammal in need thereof, and compositions related thereto, are disclosed, the methods comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound and a second antibacterial agent.