Fluorodeoxyglucose F 18

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Fluorodeoxyglucose F 18
• 英文别名: 3-(18F)fluoranyl-6-(hydroxymethyl)oxane-2,4,5-triol
• 化学式: C6H11FO5
• 分子量: 181.15
• InChiKey: ZCXUVYAZINUVJD-JZRMKITLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Method for Preparing of Organofluoro Compounds in Alcohol Solvents
  申请人：Moon Dae Hyuk

  公开号：US20080171863A1

  公开（公告）日：2008-07-17

  The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry (FIG. 1 ) as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

  本发明涉及一种制备含有放射性同位素氟-18的有机氟化合物的方法。更具体地，本发明涉及一种通过在化学品（图1）的醇溶剂存在下，将含有放射性同位素氟-18的氟盐与烷基卤或烷基磺酸盐反应，以获得高产率的有机氟化合物的方法。根据本发明的合成反应可以在温和的条件下进行，以获得高产率的有机氟化合物，并且反应时间缩短，因此适用于有机氟化合物的大规模生产。
• METHOD FOR PREPARATION OF ORGANOFLUORO COMPOUNDS IN ALCOHOL SOLVENTS
  申请人：MOON Dae Hyuk

  公开号：US20100113763A1

  公开（公告）日：2010-05-06

  The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [ 18 F]florbetaben or [ 18 F]AV-45 having and , respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

  本发明涉及一种制备含放射性同位素氟-18的有机氟化合物的方法。更具体地说，本发明涉及一种通过在化学式1的醇溶剂存在下，将含放射性同位素氟-18的氟盐与烷基卤化物或烷基磺酸酯反应，以获得高产率的有机氟化合物[18F] florbetaben或[18F] AV-45的方法，其化学式分别为11和12。根据本发明的合成反应可以在温和的条件下进行，以获得高产率的有机氟化合物，并且反应时间缩短，因此适用于有机氟化合物的大规模生产。
• Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules
  申请人：Immunomedics, Inc.

  公开号：US20140017168A1

  公开（公告）日：2014-01-16

  The present application discloses compositions and methods of synthesis and use of 18 F or 19 F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 18 F or 19 F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.

  本申请公开了用于PET、SPECT和/或MR成像的18F或19F标记分子的合成和使用方法。优选地，通过与III A族金属形成复合物，并将复合物与双官能团螯合剂结合，将18F或19F结合到靶向分子上。在其他实施例中，18F或19F标记的部分可以包括可靶向的构造物，与双特异性抗体结合以靶向疾病相关抗原。所公开的方法和组合物允许在30分钟内以非常高的效率和特异活性简单和可重复地标记分子。在优选实施例中，标记的分子可以在标记后无需纯化即可用于主体成像。
• US7847092B2
  申请人：——

  公开号：US7847092B2

  公开（公告）日：2010-12-07
• US8545809B2
  申请人：——

  公开号：US8545809B2

  公开（公告）日：2013-10-01