(3R,7S,8S)-7-methoxy-8-[(3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-2-oxaspiro[2.5]octan-6-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,7S,8S)-7-methoxy-8-[(3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-2-oxaspiro[2.5]octan-6-one
• 英文别名: (3R,4S,5S)-5-methoxy-4-[(3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-one
• 化学式: C₁₆H₂₄O₄
• 分子量: 280.36
• InChiKey: RKYFKXLMWVUYJY-SFCJMPCZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  51.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] OXASPIRO [2.5] OCTANE DERIVATIVES AND ANALOGS<br/>[FR] DÉRIVÉS D'OXASPIRO[2.5]OCTANE ET ANALOGUES
  申请人：ZAFGEN CORP

  公开号：WO2012122264A1

  公开（公告）日：2012-09-13

  The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.

  这项发明提供了氧杂螺[2.5]辛烷衍生物和类似物，其制备方法，中间体，药物组合物以及在治疗各种疾病和状况中的用途，例如超重和肥胖。
• Oxaspiro[2.5]Octane Derivatives and Analogs
  申请人：Vath James E.

  公开号：US20150045427A1

  公开（公告）日：2015-02-12

  The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.

  本发明提供了氧杂螺[2.5]辛烷衍生物和类似物，其制备方法，中间体，制药组合物以及在治疗各种疾病和病况（例如超重和肥胖）中的应用。
• PRODRUG COMPOSITIONS, PRODRUG NANOPARTICLES, AND METHODS OF USE THEREOF
  申请人：Lanza Gregory M.

  公开号：US20130122100A1

  公开（公告）日：2013-05-16

  Nanoparticles comprising a prodrug and prodrugs linked to phospholipids, wherein the linkages facilitate release of the prodrugs from the nanoparticles to sites within a target cell or cell membrane by fusion of the particle and the cell membrane are disclosed. Also disclosed are methods for producing and using the nanoparticles and their constituents.

  本发明涉及一种纳米颗粒，包括一种前药和连接到磷脂的前药，其中连接部位促进了颗粒和细胞膜的融合，从而使前药从纳米颗粒释放到目标细胞或细胞膜内的位点。还公开了制备和使用纳米颗粒及其组分的方法。
• BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES
  申请人：AKULLIAN Laura C.

  公开号：US20090148396A1

  公开（公告）日：2009-06-11

  Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.
• US8399512B2
  申请人：——

  公开号：US8399512B2

  公开（公告）日：2013-03-19