2-amino-9-[(2R,3R,5S)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl]purin-6-ol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-amino-9-[(2R,3R,5S)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl]purin-6-ol
• 英文别名: 2-amino-9-[(2R,3R,5S)-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• 化学式: C₁₀H₁₂FN₅O₃
• 分子量: 269.23
• InChiKey: ZNHBRWZXIMYBEE-OBXARNEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTIONS
  申请人：Janssen BioPharma, Inc.

  公开号：EP3797782A1

  公开（公告）日：2021-03-31

  Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.

  本文公开了核苷、核苷酸和核苷酸类似物、合成方法以及用一种或多种核苷、核苷酸和核苷酸类似物治疗冠状病毒科病毒、妥加病毒科病毒、肝病毒科病毒和/或布尼亚病毒科病毒感染等疾病和/或病症的方法。
• Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
  申请人：Lori Franco

  公开号：US20060154892A1

  公开（公告）日：2006-07-13

  A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effective to inhibit replication of said virus. Hydroxyurea is one such suitable compound. Also disclosed is a method for producing incomplete reverse- transcriptase dependent viral DNA, by administering a deoxyribonucleoside phosphate-depleting drug to cells infected with such a virus.

  一种抑制植物或动物细胞中依赖逆转录酶病毒复制的方法，包括给所述细胞施用一种化合物，该化合物能消耗细胞内的脱氧核苷磷酸池，其有效量能抑制所述病毒的复制。羟基脲就是这样一种合适的化合物。还公开了一种产生不完全逆转录酶依赖性病毒 DNA 的方法，其方法是给感染了这种病毒的细胞施用一种磷酸脱氧核苷类药物。
• 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES
  申请人：THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce

  公开号：EP0540686B1

  公开（公告）日：1995-08-30
• SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
  申请人：Alios Biopharma, Inc.

  公开号：EP3013843B1

  公开（公告）日：2018-05-30
• SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTION
  申请人：Janssen BioPharma, Inc.

  公开号：EP3160476B1

  公开（公告）日：2020-09-30