1-(4-Ethylanilino)-4-methyl-5-phenyl-imidazole-2-thiol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-Ethylanilino)-4-methyl-5-phenyl-imidazole-2-thiol
• 英文别名: 3-(4-ethylanilino)-5-methyl-4-phenyl-1H-imidazole-2-thione
• 化学式: C₁₈H₁₉N₃S
• 分子量: 309.435
• InChiKey: ZFAYRZVLWBYPJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  59.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯丙酮 、 alkaline earth salt of/the/ methylsulfuric acid 在 溴 、 溶剂黄146 作用下， 反应 0.83h， 生成 1-(4-Ethylanilino)-4-methyl-5-phenyl-imidazole-2-thiol
  参考文献：
  名称：

  N-Aminoimidazole Derivatives Inhibiting Retroviral Replication via a Yet Unidentified Mode of Action

  摘要：

  The synthesis of a series of N-aminoimidazoles (NAIMs) with an uncommon spectrum of antiretroviral activity is described. From a group of 60 closely related molecules, we were able to subdivide the molecules in different groups based on their anti-HIV and anti-SIV activity in vitro (i) molecules acting on a new, immediate postintegration step, (ii) molecules acting on both postintegration and HIV-1 reverse transcriptase (RT) as NNRTI, and (iii) molecules that mainly act at the HIV-1 RT according to an NNRTI-type mode of action.

  DOI：

  10.1021/jm0211117

文献信息

• USE OF N-AMINOIMIDAZOLE CYTOPROTECTIVE COMPOUNDS FOR TREATING CELL DEATH AND/OR GSK-3 MEDIATED DISEASES
  申请人：Pannecouque Christophe

  公开号：US20090149523A1

  公开（公告）日：2009-06-11

  The present invention relates to the use of N-aminoimidazole or N-aminoimidazole-thione derivatives as cytoprotective compounds in vitro and in vivo and for the treatment or prevention of cell death mediated disorders and/or GSK-3 mediated disorders or processes.
• [EN] USE OF N-AMINOIMIDAZOLE CYTOPROTECTIVE COMPOUNDS FOR TREATING CELL DEATH AND/OR GSK-3 MEDIATED DISEASES<br/>[FR] UTILISATION DE COMPOSÉS CYTOPROTECTEURS DE N-AMINOIMIDAZOLE POUR TRAITER DES MALADIES INDUITES PAR LA MORT CELLULAIRE ET/OU PAR GSK-3
  申请人：LEUVEN K U RES & DEV

  公开号：WO2007128088A2

  公开（公告）日：2007-11-15

  [EN] The present invention relates to the use of N-aminoimidazole or N- aminoimidazole-thione derivatives as cytoprotective compounds in vitro and in vivo and for the treatment or prevention of cell death mediated disorders and/or GSK-3 mediated disorders or processes.
  [FR] Cette invention concerne l'utilisation de dérivés de N-aminoimidazole ou de N- aminoimidazole-thione en tant que composés cytoprotecteurs in vitro et in vivo, ainsi que leur utilisation pour traiter ou prévenir des troubles induits par la mort cellulaire et/ou des processus ou des troubles induits par GSK-3.