(2R,3R,4S,5R)-2-(6-amino-1-phenylmethoxy-2H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R)-2-(6-amino-1-phenylmethoxy-2H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 化学式: C₁₇H₂₁N₅O₅
• 分子量: 375.4
• InChiKey: XBSFGURUQJDSTQ-LSCFUAHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Compounds, compositions and methods for the treatment of viral infections and other medical disorders
  申请人：Almond R. Merrick

  公开号：US20070003608A1

  公开（公告）日：2007-01-04

  The present application provides methods and compositions for improving the bioavailability of a lipid-containing antiviral compound, and in particular, an antiviral lipid-containing compound. In one embodiment, pharmaceutically acceptable compositions are provided that include an antiviral lipid-containing compound, or salt, ester, or prodrug thereof and one or more bioavailability enhancing compounds, such as inhibitors of cytochrome P450 enzymes.

  本申请提供了一种提高含脂质抗病毒化合物的生物利用度的方法和组合物，尤其是一种含脂质抗病毒化合物。在一种实施例中，提供了药学上可接受的组合物，其中包括一种含脂质抗病毒化合物或其盐、酯或前药，以及一种或多种生物利用度增强化合物，例如细胞色素P450酶抑制剂。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER MEDICAL DISORDERS
  申请人：Almond Merrick R.

  公开号：US20110015149A1

  公开（公告）日：2011-01-20

  The present application provides methods and compositions for improving the bioavailability of a lipid-containing antiviral compound, and in particular, an antiviral lipid-containing compound. In one embodiment, pharmaceutically acceptable compositions are provided that include an antiviral lipid-containing compound, or salt, ester, or prodrug thereof and one or more bioavailability enhancing compounds, such as inhibitors of cytochrome P450 enzymes.

  本申请提供了一种改善含脂质抗病毒化合物的生物利用度的方法和组合物，特别是一种含脂质抗病毒化合物。在一种实施方式中，提供了药学上可接受的组合物，包括一种含脂质抗病毒化合物或其盐、酯或前药，以及一种或多种生物利用度增强化合物，例如细胞色素P450酶抑制剂。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF POXVIRUS INFECTIONS
  申请人：Chimerix, Inc.

  公开号：EP1868628B1

  公开（公告）日：2014-06-11
• Compounds, compositions and methods for the treatment of poxvirus infections
  申请人：Almond R. Merrick

  公开号：US20070003516A1

  公开（公告）日：2007-01-04

  The present application provides methods and compositions for combination therapy with antiviral compounds for the treatment of poxvirus infections, such as orthopox virus infections. In one embodiment, a method of treatment of a poxvirus infection is provided that comprises administering to a host in need thereof cidofovir, cyclic cidofovir, or a salt, ester, or prodrug thereof in combination or alternation with at least a second anti-poxvirus agent. The second anti-poxvirus agent is, for example, a biologic, such as a pegylated interferon.
• COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20150094327A1

  公开（公告）日：2015-04-02

  The invention provides a fluorescence polarization (FP)-based assay to identify inhibitors of resolvase's DNA cleavage activity. The invention also provides resolvase inhibitors identified by the assay, as well as derivatives and analogs thereof. In certain embodiments, the compounds of the invention are useful to treat a poxvirus infection in an infected subject.