Cyclopentylethynylmethyl carbinol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Cyclopentylethynylmethyl carbinol
• 英文别名: 2-cyclopentylbut-3-yn-2-ol
• 化学式: C₉H₁₄O
• 分子量: 138.21
• InChiKey: POUOCSXBRGBQME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Inhibitors of Diacylglycerol O-acyltransferase Type 1 Enzyme
  申请人：Liu Gang

  公开号：US20080293713A1

  公开（公告）日：2008-11-27

  The present invention relates to compounds of formula (I): wherein R 1 , R 2 , and R 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT- 1 related diseases or conditions are also disclosed.

  本发明涉及式(I)的化合物，其中R1、R2和R3在此定义。还公开了治疗DGAT-1相关疾病或病状的药物组合物和方法。
• INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME
  申请人：Liu Gang

  公开号：US20120041003A1

  公开（公告）日：2012-02-16

  The present invention relates to compounds of formula (I): wherein R 1 , R 2 , and R 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

  本发明涉及式(I)的化合物：其中R1，R2和R3在此定义。还公开了治疗DGAT-1相关疾病或病状的药物组合物和方法。
• ALKYNYL ALCOHOLS AS KINASE INHIBITORS
  申请人：Chen Guoqing

  公开号：US20110086834A1

  公开（公告）日：2011-04-14

  Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.

  所选化合物对于预防和治疗炎症和炎症性疾病（如NIK介导的疾病）有效。本发明涵盖新的化合物、类似物、前药和其药学上可接受的盐、制药组合物和预防和治疗涉及炎症等疾病和其他疾病或病症的方法。
• [4.2.0]bicyclooctane derivatives, process for their preparation and pharmaceutical compositions containing same
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0196617A1

  公开（公告）日：1986-10-08

  Compounds useful in treating cardiovascular disorders' such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): wherein: n is 2 or 3; R1 is CH20H, CHO, CO2R or CO2H; R2 is hydrogen or methyl; and R3 is linear or branched alkyl having 5-10 carbon atoms, optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, in which a is 0, 1 or 2; b is 3-7; m is 0, 1 or 2; and or in which R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms; and the pharmaceutically acceptable, non-toxic salts and esters thereof.

  用于治疗心血管疾病如血栓形成、高血压和动脉粥样硬化的化合物是式 (1)、(2) 和 (3) 所示的化合物：其中：n 是 2 或 3；R1 是 CH20H、CHO、CO2R 或 CO2H；R2 是氢或甲基；R3 是具有 5-10 个碳原子的直链或支链烷基，可任选被低级烷基、低级烷氧基、三氟甲基或卤素取代，其中 a 是 0、1 或 2；b 是 3-7；m 是 0、1 或 2；或 R4 独立地是氢或具有 1-6 个碳原子的低级烷基；以及它们的药学上可接受的无毒盐和酯。
• Novel substituted (4.2.0)Bicyclooctane derivatives with valuable therapeutic properties
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0257609A2

  公开（公告）日：1988-03-02

  Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis , in inhibiting gastric acid secretion and in preventing and treating peptic and intestinal ulcers, are depicted in formulas (1), (2) and (3) : wherein: A is -C≡C-, trans -HC = CH-, -CH2CH2-or -CH=CHCH2-; X is lower alkoxy, hydroxy, or (2,2,2)-trifluoroethoxy; Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl); n is an integer of 2-4; R1 is -CH2OH, -CHO, -CO2R or -COzH, and the olefin formed by the R1(CHz) nCH = moiety is either (E) or (Z); R2 is hydrogen or methyl, or optionally -CH = CH2 when A is -CH = CHCHr; and R3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, , -(CH2)m -phenyl or CH2O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen; in which: a is an integer of 0, 1 or 2; b is an integer of 3-7; m is an integer of 0, 1 or 2; and R is wherein X is or in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

  可用于治疗心血管疾病（如血栓形成、高血压和动脉粥样硬化）、抑制胃酸分泌以及预防和治疗消化性溃疡和肠溃疡的化合物如式(1)、(2)和(3)所示： 其中 A 是-C≡C-、反式-HC = CH-、- -或-CH=CH -； X 是低级烷氧基、羟基或 (2,2,2)-三氟乙氧基； Y 是氢、外-（低级烷基）或内-（低级烷基）； n 是 2-4 的整数； R1 是- OH、-CHO、-CO2R 或-COzH，R1(CHz) nCH = 分子形成的烯烃是 (E) 或 (Z)； R2 是氢或甲基，或当 A 是-CH = CHCHr 时，任选为-CH = CH2；以及 R3 是具有 5-10 个碳原子的直链或支链烷基、烯基或炔基、 ，-( )m-苯基或 O-苯基； 其中每个苯基可任选被低级烷基、低级烷氧基、三氟甲基或卤素取代； 其中：a 是 0、1 或 2 的整数； b 是 3-7 的整数 m 是 0、1 或 2 的整数；以及 R 是 其中 X 是 或 其中每个 R4 独立地为氢或具有 1-6 个碳原子的低级烷基，及其药学上可接受的无毒盐和酯。

表征谱图