1,6-Heptadiene-3,5-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,6-Heptadiene-3,5-dione
• 英文别名: hepta-1,6-diene-3,5-dione
• 化学式: C₇H₈O₂
• 分子量: 124.14
• InChiKey: VEKIZRLWPXYFMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] ENCAPSULATES<br/>[FR] PRODUITS ENCAPSULÉS
  申请人：PROCTER & GAMBLE

  公开号：WO2013022949A1

  公开（公告）日：2013-02-14

  The present application relates to encapsulates, compositions, products comprising such encapsulates, and processes for making and using such encapsulates. Such encapsulates comprise a core comprising a perfume and a shell that encapsulates said core, such encapsulates may optionally comprise a parametric balancing agent, such shell comprising one or more azobenzene moieties.

  本申请涉及封装体、组合物、包含这种封装体的产品，以及制备和使用这种封装体的方法。这种封装体包括一个包含香水的核心和封装该核心的壳，这种封装体可以选择性地包含一个参数平衡剂，该壳包括一个或多个偶氮苯基团。
• USE OF FLAVONOIDS
  申请人：Rudolph Thomas

  公开号：US20090317342A1

  公开（公告）日：2009-12-24

  The present invention relates to the use of at least one flavonoid for odour improvement and/or odour stabilisation, and to corresponding compositions and the preparation thereof.

  本发明涉及至少一种黄酮类化合物用于改善气味和/或稳定气味，以及相应的组合物及其制备方法。
• NOVEL CURCUMINOID-INSPIRED SYNTHETIC COMPOUNDS AS ANTI-TUMOR AGENTS
  申请人：Laali Kenneth K.

  公开号：US20180362433A1

  公开（公告）日：2018-12-20

  Novel CUR- and CUR-BF 2 compounds exhibiting anti-tumor properties are presented. CUR compounds bearing fluorinated moieties with selective fluorine introduction into the α-carbonyl moiety as well as CUR-BF 2 adducts and CURs with diverse substitution patterns in the phenyl rings including fluorinated substituents (SCF 3 , OCF 3 , and F) and/or bulky activating groups (OMe, OAc, and OBz) are presented. Fluorinated aryl-pyrazoles and isoxazoles as well as novel CUR and CUR-BF 2 compounds with monocyclic aromatic and bicyclic-heteroaromatic lateral rings, bearing fluorine(s), OCF3, CF3, and SCF3 groups, and their alpha-carbonyl-fluorinated analogs, as well as their pyrazole and isoxazole derivatives are presented. The CUR-pyrazoles embody analogs that are fluorinated at the phenyl-pyrazole moiety. The compounds and their derivatives exhibited exceptional cytotoxic and anti-proliferative activity against several cancer cell-lines. Deuterated CUR-BF2 and CUR compounds were also synthesized.

  展示了具有抗肿瘤特性的新型CUR-和CUR-BF2化合物。这些CUR化合物带有氟化基团，选择性地将氟引入α-羰基部位，以及具有不同苯环取代模式的CUR- 加合物和CURs，包括氟取代基团（S ，O 和F）和/或体积庞大的活化基团（OMe，OAc和OBz）。展示了氟化芳基吡唑和异噁唑，以及具有单环芳香和双环杂芳侧链的新型CUR和CUR- 化合物，带有氟（s），O ，CF3和S 基团，以及它们的α-羰基-氟化类似物，以及它们的吡唑和异噁唑衍生物。CUR-吡唑体现了在苯基吡唑部位氟化的类似物。这些化合物及其衍生物对几种癌细胞系表现出出色的细胞毒性和抗增殖活性。还合成了氘代CUR- 和CUR化合物。
• [EN] COMPOSITION, SYNTHETIC PROCESS AND USE OF NEW ANTIOXIDANT INFLAMMATION MODULATORS<br/>[FR] COMPOSITION, PROCÉDÉ DE SYNTHÈSE ET UTILISATION DE NOUVEAUX MODULATEURS D'INFLAMMATION ANTIOXYDANTS
  申请人：UNIV RUTGERS

  公开号：WO2012145420A1

  公开（公告）日：2012-10-26

  This application discloses novel compounds and compositions for modulating in vitro and in vivo processes mediated by Nuclear Factor - Erythroid 2-Related Factor 2 (Nrf2), and as a new class of antioxidant inflammation modulators (AIM). The application also discloses methods of making and using these novel compounds, especially iminothiazinylbutadienols, divinylpyrimidinethiones and thiopyranopyridinediones, as therapeutic agents for various Nrf2, oxidative stress or inflammation related diseases or disorders.

  该应用程序披露了一种用于调节由核因子-红细胞2相关因子2（Nrf2）介导的体内和体外过程的新化合物和组合物，作为一种新的抗氧化炎症调节剂（AIM）。该应用程序还披露了制备和使用这些新化合物的方法，特别是亚硫基噻唑丁烯醇，二乙烯嘧啶硫酮和硫代吡啶二酮，作为治疗剂用于各种Nrf2、氧化应激或炎症相关疾病或疾病。
• INHIBITORS OF MITOCHONDRIAL STAT3 AND USES THEREOF IN MODULATION OF MAST CELL EXOCYTOSIS
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd

  公开号：US20160113900A1

  公开（公告）日：2016-04-28

  The invention provides composition of matter comprising at least one STAT3 inhibiting moiety or any vehicle, matrix, nano- or micro-particle comprising the same, associated with at least one mitochondrial targeting moiety. The invention further provides compositions comprising said mitochondrial-targeted STAT3 inhibitor, methods and uses thereof in inhibiting mast cell degranulation and in treating disorders induced by activation of MC.

  该发明提供了一种物质组合物，包括至少一种STAT3抑制基团或任何载体、基质、纳米或微粒，该组合物与至少一种线粒体靶向基团相关联。该发明还提供了包含所述线粒体靶向STAT3抑制剂的组合物，以及在抑制肥大细胞脱颗粒和治疗由MC激活引起的疾病中的方法和用途。