N-[4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)oxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)oxan-3-yl]acetamide
• 化学式: C14H18N2O8
• 分子量: 342.3
• InChiKey: OMRLTNCLYHKQCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  154
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-[4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)oxan-3-yl]acetamide 、 在 p-nitrophenyl 作用下， 以 Citric acid sodium citrate 、 Citric acid (trisodium) 为溶剂， 反应 0.5h， 生成 对硝基苯酚
  参考文献：
  名称：

  Test implement and test method for colorimetrically determining whether

  摘要：

  一种用于在女性生物介质中（例如唾液）进行比色测定N-乙酰-β-葡萄糖氨酸酶数量的测试实施和方法，该数量是生育或怀孕的指标。该实施是一种吸收材料，例如纸条，浸渍有N-乙酰-β-D-葡萄糖胺的酚衍生物，在存在酸性pH下与葡萄糖氨酸酶反应形成具有碱性pH下不同颜色的酚，以及维持该酸性pH的缓冲液。该方法可以通过将介质浸湿实施物，使酚形成，通过用适当的缓冲溶液浸湿实施物将pH值提高到碱性，并将实施物的颜色与颜色标准进行比较来进行。

  公开号：

  US03968011A1

文献信息

• Linkable Lewis X Analogs
  申请人：Ranganathan Ramachandran

  公开号：US20080300220A1

  公开（公告）日：2008-12-04

  Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe X ) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLe X compositions. In particular, the disclosed SLe X compounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLe X compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Le X , and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.

  本发明涉及一类可连接的四糖化合物，其中包括唾液酸Lewis X（SLeX）的氨基苯基糖苷和相关类似物。这些化合物具有可共轭的亲核基团，使它们在制备多聚SLeX组分方面非常有用。特别是，所披露的SLeX化合物可用于通过将它们连接到报告者基团（如对比剂、放射诊断剂或细胞毒素或化学治疗剂）来制备选择素结合配体共轭物。本发明的SLeX化合物和共轭物表现出与天然唾液酸LeX类似的选择素结合性，因此，它们对于诊断和治疗选择素介导的疾病和相关病症非常有用。
• LINKABLE LEWIS X ANALOGS
  申请人：Ranganathan Ramachandran

  公开号：US20110229409A1

  公开（公告）日：2011-09-22

  Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe X ) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLe X compositions. In particular, the disclosed SLe X compounds can be used to prepare selectin binding ligand con-jugatcs by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLe X compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Le X , and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.

  本文披露了一类可连接四糖化合物，其中包括唾液酸Lewis X（SLeX）的氨基苯基糖苷和相关类似物。这些化合物具有可共轭的亲核基团，因此它们在制备多聚SLeX组分方面是有用的。特别地，所披露的SLeX化合物可用于通过将它们与报告物质（如对比剂、放射性诊断剂或细胞毒素或化疗剂）连接起来，制备选择素结合配体共轭物。本发明的SLeX化合物和共轭物表现出与天然唾液酸LeX相似的选择素结合性，因此可用于诊断和治疗选择素介导的疾病和相关病症。
• Immunodulating small molecules
  申请人：AyuVis Research, Inc.

  公开号：US11364253B2

  公开（公告）日：2022-06-21

  The present invention includes novel compositions and methods for treating comprising a compound with the Formula I: where n=0-5; X═NH, O, S, CH2; Y=Phenyl, a phenyl group substituted with at least one methyl, a phenyl group substituted with at least one nitro, a phenyl group substituted with at least one nitrogen, a phenyl group substituted with at least one boron, aryl, substituted aryl, heteroaryl, four to six membered cycloalkyl, four to six membered heterocycloalkyl; R═H, C(O)R2, SO2R2; R1═H, C(O)R2, SO2R2; R2=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, NH2, NR3R4, R3, R4=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, three to six membered cycloalkyl and Z═NH, O, S, CH2 or none, wherein the amount of the compound is selected to either inhibit or activate the immune response.

  本发明包括由式 I 化合物组成的新型组合物和治疗方法： 其中n＝0-5；X═NH，O，S，CH2；Y＝苯基，被至少一个甲基取代的苯基，被至少一个硝基取代的苯基，被至少一个氮取代的苯基，芳基，取代的芳基，杂芳基，四至六位环烷基，四至六位杂环烷基；R═H，C(O)R2，SO2R2； R1═H，C(O)R2，SO2R2；R2=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, NH2, NR3R4, R3, R4=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, three to six membered cycloalkyl and Z═NH, O, S, CH2 or none, 其中化合物的量被选择为抑制或激活免疫反应。
• Abiotic Anti-VEGF Nanoparticle
  申请人：Miura Yoshiko

  公开号：US20190216744A1

  公开（公告）日：2019-07-18

  The present invention relates generally to compositions and methods comprising abiotic, synthetic polymers with affinity and specificity to proteins. The synthetic polymers are an improvement over biological agents by providing a simpler, less expensive, and customizable platform for binding to proteins. In one embodiment, the compositions and methods relate to synthetic polymers with affinity and specificity to vascular endothelial growth factor (VEGF). In one embodiment, the compositions are useful for treating diseases and disorders related to the overexpression of VEGF. In one embodiment, the compositions are useful for treating cancer. In one embodiment, the compositions are useful for detecting VEGF levels from biological samples. In one embodiment, the compositions are useful for detecting overexpression of VEGF from biological samples. In one embodiment, the compositions are used to diagnose cancer.
• US7422733B2
  申请人：——

  公开号：US7422733B2

  公开（公告）日：2008-09-09