3,5-Bis(phenylmethoxy)-6-(phenylmethoxymethyl)oxane-2,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,5-Bis(phenylmethoxy)-6-(phenylmethoxymethyl)oxane-2,4-diol
• 化学式: C₂₇H₃₀O₆
• 分子量: 450.5
• InChiKey: CXVPIMVTYWPRQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Vaccines against Streptococcus pneumoniae serotype 5
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：US10596272B2

  公开（公告）日：2020-03-24

  The present invention relates to well-defined synthetic saccharides of general formula (I) that are related to the repeating unit of Streptococcus pneumoniae serotype 5 capsular polysaccharide and conjugates thereof. The conjugates and pharmaceutical compositions containing said conjugates are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae serotype 5. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.

  本发明涉及与肺炎链球菌血清 5 型荚膜多糖重复单元有关的通式（I）的定义明确的合成糖类及其共轭物。所述共轭物和含有所述共轭物的药物组合物可用于预防和/或治疗与肺炎链球菌相关的疾病，更具体地说，可用于预防和/或治疗与肺炎链球菌血清 5 型相关的疾病。此外，通式（I）的合成糖类可作为免疫学试验中的标记物，用于检测针对肺炎链球菌的抗体。
• [EN] SYNTHESIS OF HELICOBACTER PYLORI O2 SEROTYPE O-ANTIGEN OLIGOSACCHARIDE COMPOUND<br/>[FR] SYNTHÈSE D'UN COMPOSÉ O-ANTIGÈNE OLIGOSACCHARIDE D'HELICOBACTER PYLORI DE SÉROTYPE O2<br/>[ZH] 一种幽门螺旋杆菌O2血清型O抗原寡糖类化合物的合成
  申请人：UNIV JIANGNAN

  公开号：WO2020155519A1

  公开（公告）日：2020-08-06

  本发明公开了一种幽门螺旋杆菌O2血清型O抗原寡糖类化合物的合成，属于有机合成领域。本发明通过化学合成得到幽门螺旋杆菌O2血清型O-抗原二糖至二十四糖。本发明利用保护剂策略、温度效应、溶剂效应和添加剂效应，开发了一种非常有利于葡萄糖α糖苷键生成的化学合成方法。将此方法用于合成组装有氨基连接臂的幽门螺旋杆菌O2血清型O-抗原寡糖类化合物；合成得到的组装有氨基连接臂的幽门螺旋杆菌O2血清型O-抗原寡糖类化合物可以与载体蛋白制成糖缀合物，用于免疫学研究，对发展预防和治疗幽门螺旋杆菌具有重要作用。
• Synthesis of O-Antigen oligosaccharide Compounds of Helicobacter Pylori Serotype O2
  申请人：Jiangnan University

  公开号：US20200331951A1

  公开（公告）日：2020-10-22

  Disclosed is synthesis of an O-Antigen oligosaccharide compound of Helicobacter pylori serotype O2, belonging to the field of organic synthesis. The disclosure obtains O-antigen disaccharide to tetracosasaccharide of Helicobacter pylori serotype O 2 by chemical synthesis. A chemical synthesis method which is quite conducive to production of a glucose-α-glucosidic bond is developed in the disclosure by a protectant strategy, temperature effect, solvent effect, and additive effect. The method is applied in synthesis of an O-antigen oligosaccharide compound of Helicobacter pylori serotype O2 assembled with an amino linking arm. A saccharide conjugate can be prepared from the synthesized O-antigen oligosaccharide compound of Helicobacter pylori serotype O2 assembled with an amino linking arm together with a carrier protein for immunology researches, playing an important role in preventing and treating Helicobacter pylori.