Ethyl 2,3,4,6-tetra-o-benzyl-beta-d-thioglucopyranoside

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Ethyl 2,3,4,6-tetra-o-benzyl-beta-d-thioglucopyranoside
• 英文别名: 2-ethylsulfanyl-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxane
• 化学式: C₃₆H₄₀O₅S
• 分子量: 584.777
• InChiKey: NRALMNQUAKWSMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  42
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from pseudomonas
  申请人：Magnani L. John

  公开号：US20070037775A1

  公开（公告）日：2007-02-15

  Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.

  提供与铜绿假单胞菌相关的组合物和方法。这些组合物和方法可用于诊断和治疗涉及铜绿假单胞菌感染的医疗状况。这些感染包括囊性纤维化患者肺部中的铜绿假单胞菌。在目前的方法中有用的化合物可以与治疗剂结合使用，或者可以与治疗剂连接。通过阻止定植、抑制毒力因子、阻止生长或杀死细菌可以抑制铜绿假单胞菌。
• [EN] GLYCOMIMETIC INHIBITORS OF PA-IL AND PA-IIL LECTINS<br/>[FR] INHIBITEURS GLYCOMIMÉTIQUES DES LECTINES PA-IL ET PA-IIL
  申请人：GLYCOMIMETICS INC

  公开号：WO2017127422A1

  公开（公告）日：2017-07-27

  Compounds, compositions, and methods for the diagnosis and/or treaimeni of medical conditions involving infections with and colonization by Fseudomonas bacteria including, for example, Fseudomonas aeruginosa in the lungs of patients with cystic fibrosis are described.

  描述了涉及感染和定植由铜绿假单胞菌引起的医疗状况的诊断和/或治疗的化合物、组合物和方法，例如囊性纤维化患者肺部中的铜绿假单胞菌。
• Glycomimetic inhibitors of PA-IL and PA-IIL lectins
  申请人：GlycoMimetics, Inc.

  公开号：US11045485B2

  公开（公告）日：2021-06-29

  Compounds, compositions, and methods for the diagnosis and/or treatment of medical conditions involving infections with and colonization by Pseudomonas bacteria including, for example, Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis are described.

  本文描述了用于诊断和/或治疗囊性纤维化患者肺部假单胞菌感染和定植病症的化合物、组合物和方法，这些假单胞菌包括铜绿假单胞菌等。
• GLYCOMIMETIC INHIBITORS OF PA-IL AND PA-IIL LECTINS
  申请人：GlycoMimetics, Inc.

  公开号：EP3405473A1

  公开（公告）日：2018-11-28
• GLYCOMIMETIC INHIBITORS OF THE PA-IL LECTIN, PA-IIL LECTIN OR BOTH THE LECTINS FROM PSEUDOMONAS
  申请人：Magnani John L.

  公开号：US20100041626A1

  公开（公告）日：2010-02-18

  Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.