[6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methanol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methanol
• 化学式: C₂₈H₃₂O₆
• 分子量: 464.5
• InChiKey: MOKYEUQDXDKNDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Alpha-selective sialyl donor and its uses for preparation of sialosides
  申请人：Chung Yuan Christian University

  公开号：US10435425B1

  公开（公告）日：2019-10-08

  Disclosed herein a sialyl donor and its use for the synthesis of gangliosides. The sialyl donor has the structure of, wherein, R1 and R2 are independently benzoyl, toluenesulfonyl, pivaloyl or acetyl optionally substituted with a halogen; and R3 is acetyl or —(O)CCH2OH. In one preferred embodiment, in the sialyl donor of formula (I), R is acetyl. Also disclosed herein is a method of synthesizing a sialoside. The method comprises steps of: coupling the sialyl donor of formula (I) with a glycosyl acceptor having a primary hydroxyl group in the presence of N-iodosuccinimide (NIS) and trifluoromethanesulfonic acid (TfOH) under suitable conditions; and isolating the sialoside, which has an α-glycosidic linkage. According to preferred embodiments, the coupling is conducted in a solvent selected from the group consisting of, CH3CN, CH3Cl, and CH2Cl2 at a temperature between −20° C. to −60° C. Additionally or optionally, the coupling is conducted in CH2Cl2 with the presence of a powdered molecular sieve at −40° C.

  本公开揭示了一种唾液酸供体及其用于合成神经节苷脂的用途。该唾液酸供体的结构为， 其中，R1和R2独立地为苯甲酰基、甲苯磺酰基、季戊酰基或乙酰基，可选择地被卤素取代；R3为乙酰基或—(O)CCH2OH。在一个首选实施例中，在式(I)的唾液酸供体中，R为乙酰基。本公开还揭示了一种合成唾苷的方法。该方法包括以下步骤：在适当条件下，将式(I)的唾液酸供体与具有主要羟基的糖基受体在N-碘代琥珀酰亚胺（NIS）和三氟甲磺酸（TfOH）的存在下偶联；并分离具有α-糖苷键的唾苷，根据首选实施例，偶联在从CH3CN、CH3Cl和CH2Cl2组成的溶剂中，在-20°C至-60°C的温度下进行。此外或可选地，在-40°C时，在CH2Cl2中存在粉末分子筛的情况下进行偶联。
• iNKT cell modulators and methods of using the same
  申请人：LUDWIG INSTITUTE FOR CANCER RESEARCH

  公开号：US10314796B2

  公开（公告）日：2019-06-11

  Disclosed herein are α-galactosylceramide (α-GalCer) analogs and compositions thereof, methods of activating invariant Natural Killer T (iNKT) cells using said analogs, methods of treating diseases by activating iNKT cells using said analogs, and combination therapy of said analogs.

  本文公开了α-半乳糖甘油酰胺（α-GalCer）类似物及其组合物、使用所述类似物激活不变杀伤性T细胞（iNKT）的方法、通过使用所述类似物激活iNKT细胞治疗疾病的方法以及所述类似物的联合疗法。
• USE OF IGF-2 RECEPTOR AGONIST LIGANDS FOR TREATMENT OF ANGELMAN SYNDROME AND AUTISM
  申请人：New York University

  公开号：US20210315914A1

  公开（公告）日：2021-10-14

  Provided are methods for treatment of neurodevelopmental disorders, such as Angelman Syndrome and autism comprising administering to an individual a composition comprising an agonist ligand of IGF-2 receptor. The agonist ligand of IGF-2 receptor may be IGF-2, or mannose-6-phosphate or a derivative thereof. Compositions comprising mannose-6-phosphate derivatives are also disclosed.
• US9700532B2
  申请人：——

  公开号：US9700532B2

  公开（公告）日：2017-07-11