5-Phenyl-2-(4-phenyl-thiazol-2-yl)-2,4-dihydro-pyrazol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Phenyl-2-(4-phenyl-thiazol-2-yl)-2,4-dihydro-pyrazol-3-one
• 英文别名: 5-phenyl-2-(4-phenyl-1,3-thiazol-2-yl)-4H-pyrazol-3-one
• 化学式: C₁₈H₁₃N₃OS
• 分子量: 319.4
• InChiKey: MCYPSFONYBCDGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  73.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Pyrazol-3-ones that activate pro-apoptotic BAX
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US10844053B2

  公开（公告）日：2020-11-24

  This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).

  本申请的特点是吡唑-3-酮化合物能激活促细胞凋亡的 BAX。此外，还介绍了使用此类化合物的方法，例如，用于治疗或预防与细胞凋亡失调（例如，病变或受损细胞凋亡不足或病变或受损细胞基本上没有凋亡）有关的疾病、失调和病症。
• PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20190315730A1

  公开（公告）日：2019-10-17

  This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).