α-Oxalylstearinsaeure-diethylester | 91889-13-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: α-Oxalylstearinsaeure-diethylester
• 英文别名: hexadecyl-oxalacetic acid diethyl ester；Hexadecyl-oxalessigsaeure-diaethylester；Diethyl 2-hexadecyl-3-oxobutanedioate
• CAS: 91889-13-3
• 化学式: C₂₄H₄₄O₅
• 分子量: 412.61
• InChiKey: SFKXFSUPLYQWEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  29
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  α-Oxalylstearinsaeure-diethylester 生成 十六烷基丙二酸
  参考文献：
  名称：

  尝试合成木耳酸。交流三：关于碘乙酸乙酯与α-草酰硬脂酸二乙酯的加成

  摘要：

  在锌-铜对催化下，碘乙酸乙酯可加成到α-草酰硬脂酸二乙酯的羰基上。这以2.6%的产率得到外消旋木耳酸。合成分离并鉴定为二乙酯或二乙酯单钾盐。

  DOI：

  10.1002/ardp.19733060509
• 作为产物：
  描述：

  硬脂酸乙酯 、 草酸二乙酯 在 sodium ethanolate 作用下， 生成 α-Oxalylstearinsaeure-diethylester
  参考文献：
  名称：

  尝试合成木耳酸。交流三：关于碘乙酸乙酯与α-草酰硬脂酸二乙酯的加成

  摘要：

  在锌-铜对催化下，碘乙酸乙酯可加成到α-草酰硬脂酸二乙酯的羰基上。这以2.6%的产率得到外消旋木耳酸。合成分离并鉴定为二乙酯或二乙酯单钾盐。

  DOI：

  10.1002/ardp.19733060509

文献信息

• Treatment with diazoxide causes prolonged improvement of β-cell function in rat islets transplanted to a diabetic environment
  作者：S. Hiramatsu、A. Höög、C. Möller、V. Grill

  DOI：10.1016/s0026-0495(00)80044-x

  日期：2000.5

  Prolonged hyperglycemia desensitizes beta cells. A role for hyperglycemia-induced excessive stimulation can be tested by diazoxide, which inhibits glucose-induced insulin secretion. Using diazoxide, we have investigated in a rat transplantation model whether excessive stimulation can induce lasting effects on beta cells. One batch with 150 islets and another with 20 islets isolated from Wistar-Furth rats were transplanted under the left-kidney capsule of syngeneic streptozotocin-diabetic recipients. In a first series, recipients were treated for 8 weeks with or without 0.2% diazoxide in the food. Graft-bearing kidneys were then perfused and excised. Diazoxide treatment increased by 5.5;fold the insulin response to 10 mmol/L arginine, by 4.1-fold the graft insulin content, and by 2.3-fold the preproinsulin mRNA versus nontreated diabetic controls. The persistence of these effects was assessed in a second series in which 8 weeks of diazoxide treatment was followed by 1 week of no treatment. Again, perfusion experiments showed a higher insulin response to arginine in diazoxide-treated rats (136.0 +/- 25.7 v 62.3 +/- 11.8 fmol/min, P < .05). Also, the response to 27.8 mmol/L glucose was increased (54.0 +/- 17.1 v 13.6 +/- 7.8 fmol/min, P < .05). The insulin content was increased (2.2 +/- 0.6 v 1.0 +/- 0.4 pmol/islet, P < .05), as well as the preproinsulin mRNA (0.60 +/- 0.08 v 0.22 +/- 0.02 pg/islet, P < .05). In a third series, we tested the impact of diazoxide treatment when given only during the first 2 weeks following transplantation. When tested 6 weeks later, insulin secretion was unaffected, whereas there was a strong tendency for a higher preproinsulin mRNA and insulin content in grafts of diazoxide;treated rats. In conclusion, this study demonstrates that beta-cell function in transplanted islets is improved by diazoxide long after the end of treatment, an effect that is likely due to removal of hyperglycemia induced excessive stimulation. Copyright (C) 2000 by W.B. Saunders Company.
• Floyd; Miller, Journal of the American Chemical Society, 1947, vol. 69, p. 2355
  作者：Floyd、Miller

  DOI：——

  日期：——
• Ester condensation
  申请人：GEN MILLS INC

  公开号：US02523692A1

  公开（公告）日：1950-09-26
• Schreiber, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1955, vol. 240, p. 2536
  作者：Schreiber

  DOI：——

  日期：——
• Schreiber, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1956, vol. 242, p. 139
  作者：Schreiber

  DOI：——

  日期：——