4,5-Bis-(2-thienyl)-1H-imidazol | 67947-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-Bis-(2-thienyl)-1H-imidazol
• 英文别名: 4,5-di-thiophen-2-yl-1H-imidazole；4,5-bis-(thien-2-yl)-1H-imidazole；4,5-bis-(2-thienyl)-1H-imidazole；Dithienylimidazol；4,5-dithiophen-2-yl-1H-imidazole
• CAS: 67947-41-5
• 化学式: C₁₁H₈N₂S₂
• 分子量: 232.33
• InChiKey: BADMPUNGMZZJOP-UHFFFAOYSA-N

物化性质

• 沸点：
  425.6±35.0 °C(Predicted)
• 密度：
  1.362±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  环丁砜 、 4,5-Bis-(2-thienyl)-1H-imidazol 在 硫化氢 作用下， 以 N-甲基乙酰胺 、 乙腈 为溶剂， 生成 2-mercapto-4,5-bis-(thien-2-yl)-imidazole
  参考文献：
  名称：

  Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their

  摘要：

  抗炎性4,5-二环-2-(取代硫)-咪唑及其相应的亚砜和磺酰化物，例如4-(4-氟苯基)-2-(1,1,2,2-四氟乙基磺酰基)-5-(2-噻吩基)-1H-咪唑，可用于治疗关节炎和相关疾病。

  公开号：

  US04159338A1

文献信息

• IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTIONS
  申请人：Axxima Pharmaceuticals Aktiengesellschaft

  公开号：EP1532118A2

  公开（公告）日：2005-05-25
• Imidazole compounds and human cellular proteins casein kinase I alpha, delta and epsilon as targets for medical intervention against Hepatitis C Virus infections
  申请人：Salassidis Konstadinos

  公开号：US20050203155A1

  公开（公告）日：2005-09-15

  Novel imidazole compounds particularly useful against Hepatitis C Virus infections and diseases associated therewith are described. Applications of the human cellular proteins casein kinase I alpha (α), delta (δ), and epsilon (ε) as targets for medical intervention against Hepatitis C Virus (HCV) infections and diseases are also described. This invention further refers to a method for identifying compounds useful for the prophylaxis and/or treatment of Hepatitis C Virus infections and diseases, methods for treating Hepatitis C Virus infections and diseases, as well as pharmaceutical compositions useful for the prophylaxis and/or treatment of Hepatitis C Virus infections and diseases. Moreover, disclosed are antibodies, oligonucleotides and specific compounds which are effective for the detection, prophylaxis and/or treatment of Hepatitis C Virus infections and diseases. Solid supports useful for the identification of compounds suitable for preventing and/or treating Hepatitis C Virus infections and diseases are also disclosed.
• US4159338A
  申请人：——

  公开号：US4159338A

  公开（公告）日：1979-06-26
• US4524123A
  申请人：——

  公开号：US4524123A

  公开（公告）日：1985-06-18
• [EN] IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTIONS<br/>[FR] COMPOSES D'IMIDAZOLE ET PROTEINES CELLULAIRES HUMAINES CASEINE KINASE I ALPHA, DELTA ET EPSILON UTILISES COMME CIBLE LORS D'INTERVENTIONS MEDICALES CONTRE DES INFECTIONS PAR LE VIRUS DE L'HEPATITE C
  申请人：AXXIMA PHARMACEUTICALS AG

  公开号：WO2004005264A2

  公开（公告）日：2004-01-15

  The present invention describes novel imidazole compounds, which are particularly useful against Hepatitis C Virus infections and diseases associated therewith. Furthermore, the invention relates to the human cellular proteins casein kinase I alpha (α), delta (δ), and epsilon (ϵ) as targets for medical intervention against Hepatitis C Virus (HCV) infections and diseases. In addition, the present invention refers to a method for the identification of compounds which are useful for the prophylaxis and/or treatment of infections and diseases caused by Hepatitis C Virus, methods for treating Hepatitis C Virus infections and diseases, as well as pharmaceutical compositions useful for the prophylaxis and/or treatment of Hepatitis C Virus infections and diseases. Moreover, disclosed are antibodies, oligonucleotides and specific compounds which are effective for the detection, prophylaxis and/or treatment of infections and diseases caused by Hepatitis C Virus. In addition, the present invention describes solid supports useful for the identification of compounds suitable for preventing and/or treating infections and diseases caused by said Hepatitis C Virus.