1,4-Dioxadispiro[4.1.4.3]tetradecane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-Dioxadispiro[4.1.4.3]tetradecane
• 英文别名: 8,11-dioxadispiro[4.1.47.35]tetradecane
• 化学式: C₁₂H₂₀O₂
• 分子量: 196.29
• InChiKey: GXRBACBELHPUJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• N-ARYL AZASPIROALKENE AND AZASPIROALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF
  申请人：Bhatti Balwinder

  公开号：US20100240689A1

  公开（公告）日：2010-09-23

  Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl or heteroaryl azaspiroalkene/alkane compounds, prodrugs or metabolites of these compounds, or pharmaceutically acceptable salts thereof. The aryl group can be a phenyl ring or a five- or six-membered heterocyclic ring (heteroaryl). The compounds and compositions can be used to treat and/or prevent a wide variety of conditions or disorders, particularly those disorders characterized by dysfunction of nicotinic cholinergic neurotransmission, including disorders involving neuromodulation of neurotransmitter release, such as dopamine release. CNS disorders, which are characterized by an alteration in normal neurotransmitter release, are another example of disorders that can be treated and/or prevented. The compounds and compositions can also be used to alleviate pain. The compounds can: (i) alter the number of nicotinic cholinergic receptors of the brain of the patient, (ii) exhibit neuroprotective effects and (iii) when employed in effective amounts, not result in appreciable adverse side effects (e.g., side effects such as significant increases in blood pressure and heart rate, significant negative effects upon the gastro-intestinal tract, and significant effects upon skeletal muscle).

  本发明涉及一种N-芳基或杂环芳基的氮杂螺烯/烷化合物，这些化合物的前药或代谢物，或其药学上可接受的盐的制备和使用方法，以及包括这些化合物的制药组合物。芳基可以是苯环或五元或六元杂环环（杂环芳基）。这些化合物和组合物可用于治疗和/或预防各种疾病或障碍，特别是那些以尼古丁性胆碱能神经递质功能障碍为特征的障碍，包括涉及神经递质释放的神经调节障碍，如多巴胺释放。中枢神经系统障碍，其特征是正常神经递质释放的改变，是可以治疗和/或预防的另一个例子。这些化合物和组合物也可用于缓解疼痛。这些化合物可以：（i）改变患者大脑中尼古丁性胆碱能受体的数量，（ii）表现出神经保护作用，（iii）在有效剂量下使用时，不会产生明显的不良副作用（例如，明显增加血压和心率，对胃肠道产生显著的负面影响和对骨骼肌产生显著的影响等副作用）。

表征谱图