2-(2-Imino-3-methyl-benzimidazol-1-yl)-1-(4-phenylphenyl)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-Imino-3-methyl-benzimidazol-1-yl)-1-(4-phenylphenyl)ethanone
• 英文别名: 2-(2-imino-3-methylbenzimidazol-1-yl)-1-(4-phenylphenyl)ethanone
• 化学式: C₂₂H₁₉N₃O
• 分子量: 341.4
• InChiKey: LLKFOUBQMFACAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  47.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOUNDS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES
  申请人：Horrigan Stephen K.

  公开号：US20100093611A1

  公开（公告）日：2010-04-15

  Methods of treating, ameliorating, preventing, or reducing the risk of developing an auto-immune disease and/or an inflammatory condition, such as systemic lupus erythematosus, in a patient, such as a human being, using a therapeutically effective amount of an agent(s) that inhibits the activity of one or more of histone deacetylase (HDAC), I K B kinase (IKK-2), nuclear factor kB (NF-kB), ubiquitin/proteasome and Janus kinase (JAK) are disclosed. Compounds useful in such methods are also presented.