1,3,5-Trimethyl-4-propionyl-pyrazol | 90721-80-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,3,5-Trimethyl-4-propionyl-pyrazol
• 英文别名: 1-(trimethyl-1H-pyrazol-4-yl)propan-1-one；1-(1,3,5-trimethylpyrazol-4-yl)propan-1-one
• CAS: 90721-80-5
• 化学式: C₉H₁₄N₂O
• mdl: MFCD00514540
• 分子量: 166.223
• InChiKey: XYCNZUWSRXFCSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• FUSED HETEROCYCLIC COMPOUNDS AS SODIUM CHANNEL MODULATORS
  申请人：Gilead Sciences, Inc.

  公开号：EP2707361B1

  公开（公告）日：2017-08-23
• FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
  申请人：Gilead Sciences, Inc.

  公开号：US20160362421A1

  公开（公告）日：2016-12-15

  The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R 1 , X 1 , X 2 , Y and R 2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
• US9682998B2
  申请人：——

  公开号：US9682998B2

  公开（公告）日：2017-06-20