4-chloro-N-{8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-1,2-diazabenzo[e]azulene-3-carbonyl}benzenesulfonamide | 878379-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-chloro-N-{8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-1,2-diazabenzo[e]azulene-3-carbonyl}benzenesulfonamide
• 英文别名: 4-Chloro-N-{8-chloro-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carbonyl)-benzene-sulfonamide；12-chloro-N-(4-chlorophenyl)sulfonyl-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),4,11,13-pentaene-5-carboxamide
• CAS: 878379-12-5
• 化学式: C₂₅H₁₇Cl₄N₃O₃S
• 分子量: 581.306
• InChiKey: GTLILAWYEINGHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  89.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-N-{8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-1,2-diazabenzo[e]azulene-3-carbonyl}benzenesulfonamide 、 甲胺 在 五氯化磷 作用下， 以 氯苯 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 4-chloro-N-{[8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-1,2-diazabenzo[e]azulen-3-yl]-methylamino-methylene}benzenesulfonamide
  参考文献：
  名称：

  [EN] TRICYCLIC PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS
  [FR] NOUVEAUX COMPOSES HETEROCYCLIQUES

  摘要：

  公开号：

  WO2006025069A3
• 作为产物：
  描述：

  、 4-氯苯磺酰胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 4-chloro-N-{8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-1,2-diazabenzo[e]azulene-3-carbonyl}benzenesulfonamide
  参考文献：
  名称：

  [EN] TRICYCLIC PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS
  [FR] NOUVEAUX COMPOSES HETEROCYCLIQUES

  摘要：

  公开号：

  WO2006025069A3

文献信息

• Tricyclic Pyrazole Derivatives as Cannabinoid Receptor Modulators
  申请人：Lohray Bhushan Braj

  公开号：US20080051386A1

  公开（公告）日：2008-02-28

  The present invention relates to novel compounds of general formula (I), their regioisomers, tautomeric forms, novel intermediates involved in their synthesis. The present invention also relates to a process of preparing compounds of general formula (I), their regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

  本发明涉及一般式(I)的新化合物、它们的区异构体、互变异构体及其合成中涉及的新中间体。本发明还涉及制备一般式(I)的化合物、它们的区异构体、互变异构体、药学上可接受的盐、包含它们的制药组合物以及合成中涉及的新中间体的方法。
• TRICYCLIC PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS
  申请人：LOHRAY Braj Bhushan

  公开号：US20100273791A1

  公开（公告）日：2010-10-28

  The present invention relates to novel compounds of general formula (I), their regioisomers, tautomeric forms, novel intermediates involved in their synthesis. The present invention also relates to a process of preparing compounds of general formula (I), their regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

  本发明涉及一般式（I）的新化合物、它们的区域异构体、互变异构体以及其合成中所涉及的新中间体。本发明还涉及制备一般式（I）的化合物、它们的区域异构体、它们的互变异构体、它们的药学上可接受的盐、含有它们的制药组合物以及其合成中所涉及的新中间体的方法。
• Tricyclic pyrazole derivatives as cannabinoid receptor modulators
  申请人：Cadila Healthcare Limited

  公开号：US08030345B2

  公开（公告）日：2011-10-04

  The present invention relates to novel compounds of general formula (I), their regioisomers, tautomeric forms, novel intermediates involved in their synthesis. The present invention also relates to a process of preparing compounds of general formula (I), their regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

  本发明涉及一般式(I)的新化合物、它们的区域异构体、互变异构体、参与它们合成的新中间体。本发明还涉及制备一般式(I)化合物、它们的区域异构体、互变异构体、药学上可接受的盐、含有它们的药物组合物以及参与它们合成的新中间体的方法。
• US8030345B2
  申请人：——

  公开号：US8030345B2

  公开（公告）日：2011-10-04
• [EN] TRICYCLIC PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS<br/>[FR] NOUVEAUX COMPOSES HETEROCYCLIQUES
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2006025069A3

  公开（公告）日：2006-04-27