2-Methyl-1-(3,4,5-trihydroxyphenyl)propan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-1-(3,4,5-trihydroxyphenyl)propan-1-one
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.2
• InChiKey: CJSBGEKYQQNHEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• TRIPEPTIDE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
  申请人：NORTHWEST UNIVERSITY

  公开号：US20170267718A1

  公开（公告）日：2017-09-21

  Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula (I). The provided compound has angiotensin converting enzyme inhibiting bioactivity, and the compound and a pharmaceutical composition thereof play a role in preventing and treating hypertension and other cardiocerebral vascular system diseases.

  提供了一种三肽化合物，其制备方法和应用。相关化合物的结构由式（I）表示。提供的化合物具有抑制血管紧张素转换酶的生物活性，该化合物及其药物组成对预防和治疗高血压和其他心脑血管系统疾病起着作用。
• Non-Glycosylated/Non-Glycosidic/Non-Peptidic Small Molecule Psgl-1 Mimetics for the Treatment of Inflammatory Disorders
  申请人：Kranich Remo

  公开号：US20080249107A1

  公开（公告）日：2008-10-09

  Pharmaceutical compositions comprising at least one compound of the formulas (Ia) or (Ib) and a pharmaceutically acceptable carrier which is useful in a medicine wherein the symbols, indices and substituents have the following meaning R 1 ═H, CN, NO 2 , CF 3 , F, Cl, Br, I, CH 3 R 2 ═H, CN, NO 2 , CF 3 , F, Cl, Br, I, CH 3 , Et, n-Pr, i-Pr, n-Bu, t-Bu, phenyl, thienyl, furyl, thiazolyl and either R 1 or R 2 must be H R 3 ═H, CN, NO 2 , CF 3 , F, Cl, Br, I, CH 3 , Et, n-Pr, i-Pr, n-Bu, t-Bu, phenyl, thienyl, furyl, thiazolyl then X is e.g. with R 4 being H, CH 3 , CH 2 CH 3 or and Y being or the pharmaceutically acceptable salts, esters or amides and prodrugs of the above identified compounds of formulas (Ia) or (Ib). The compounds are applied to modulate the in-vitro and in-vivo binding processes mediated by E-, P- or L-selectin binding.

  含有式(Ia)或(Ib)中至少一种化合物和药学上可接受的载体的制药组合物，在医学上有用。其中符号、指数和取代基的含义如下： R1═H、CN、NO2、CF3、F、Cl、Br、I、CH3 R2═H、CN、 、 、F、Cl、Br、I、 、Et、n-Pr、i-Pr、n-Bu、t-Bu、苯基、噻吩基、呋喃基、噻唑基，且R1或R2中必须有一个为H R3═H、CN、 、 、F、Cl、Br、I、 、Et、n-Pr、i-Pr、n-Bu、t-Bu、苯基、噻吩基、呋喃基、噻唑基 然后X为例如，R4为H、 、CH2 或，Y为或上述式(Ia)或(Ib)中识别的化合物的药学上可接受的盐、酯或酰胺以及前药。这些化合物被应用于调节由E、P或L选择素结合介导的体内和体外结合过程。
• ACYL PIPERIDINE INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
  申请人：Hammock Bruce D.

  公开号：US20130143925A1

  公开（公告）日：2013-06-06

  Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.

  提供可用于治疗疾病的可溶性环氧酶（sEH）抑制剂，其中包含多个药效团。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR PROTECTING BRAIN HEALTH IN NEURODEGENERATIVE DISORDERS
  申请人：Amazetis SA

  公开号：EP3202399A1

  公开（公告）日：2017-08-09

  Aspects of the invention relate to compounds, extracts and compositions thereof, and methods of using of the same, to treat neurodegenerative disorders and/or improve brain health. In certain embodiments, said compounds are pomegranate flavonoids.

  本发明的各个方面涉及治疗神经退行性疾病和/或改善大脑健康的化合物、提取物及其组合物以及使用方法。在某些实施方案中，所述化合物是石榴类黄酮。
• Compositions and methods for glucose transport inhibition
  申请人：OHIO UNIVERSITY

  公开号：US10000443B2

  公开（公告）日：2018-06-19

  Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research.

  在癌症研究和治疗中，葡萄糖剥夺是一种极具吸引力的策略。癌细胞会上调葡萄糖摄取和新陈代谢，以维持加速生长和增殖速度。专门阻断这些过程有可能为了解葡萄糖转运和代谢在肿瘤发生和凋亡中的作用提供新的视角。随着实体瘤向周围血管外生长，它们会遇到营养供应有限的微环境，导致肿瘤的某些区域出现葡萄糖匮乏的环境。生活在葡萄糖匮乏环境中的癌细胞会发生变化，以防止葡萄糖匮乏诱导的细胞凋亡。了解癌细胞如何逃避凋亡诱导，还可能获得关于如何克服癌细胞对凋亡诱导的抗性的有价值的信息和知识。本文公开了新型抗癌化合物，这些化合物可抑制基础葡萄糖转运，从而抑制肿瘤，还公开了在动物癌症研究中研究葡萄糖剥夺的新方法。