5-phenyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol | 40494-52-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-phenyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol
• 英文别名: 5-Phenyl-6,7,8,9-tetrahydrobenzo[7]annulen-5-ol
• CAS: 40494-52-8
• 化学式: C₁₇H₁₈O
• 分子量: 238.329
• InChiKey: WOYUSQGAAJDBHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  387.0±11.0 °C(Predicted)
• 密度：
  1.115±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-phenyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol 在 碘 作用下， 反应 0.03h， 以93%的产率得到9-phenyl-6,7-dihydro-5H-benzocycloheptene
  参考文献：
  名称：

  Iodine induced transformations of alcohols under solvent-free conditions

  摘要：

  Iodine has been shown to be an efficient catalyst for transformations of alcohols under solvent-free conditions. In the presence of 5% of iodine, tertiary alcohols underwent dehydration forming the corresponding alkenes, while in the case of 2-phenylpropane-2-ol cyclodimerisation to 1,1,3-trimethyl-3-phenylindane took place. Secondary and primary benzyl alcohols under the same conditions gave the corresponding ethers. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.154
• 作为产物：
  描述：

  phenylmagnesium bromide 、 1-苯并环庚酮 在 乙醚 作用下， 生成 5-phenyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol
  参考文献：
  名称：

  Protiva; Borovicka, Collection of Czechoslovak Chemical Communications, 1951, vol. 16/17, p. 57,63

  摘要：

  DOI：

文献信息

• PHOSPHOROAMIDE COMPOUND, METHOD FOR PRODUCING THE SAME, LIGAND, COMPLEX, CATALYST, AND METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL
  申请人：National University Corporation Nagoya University

  公开号：EP2128167A1

  公开（公告）日：2009-12-02

  Disclosed is a method for highly efficiently obtaining an optically active alcohol from a carbonyl compound highly enantioselectively. Also disclosed is a ligand used in such a method. Specifically, an optically active alcohol is obtained by reacting a carbonyl compound and an organozinc compound by using a ligand (L) shown below.

  本发明公开了一种从羰基化合物中高效对映选择性地获得光学活性醇的方法。还公开了一种用于这种方法的配体。具体地说，通过使用下图所示的配体（L），使羰基化合物和有机锌化合物反应，得到光学活性醇。
• Gootjes; Funcke; Timmerman, Arzneimittel-Forschung/Drug Research, 1972, vol. 22, # 12, p. 2070 - 2073
  作者：Gootjes、Funcke、Timmerman、Nauta

  DOI：——

  日期：——
• PHOSPHORAMIDE COMPOUND, METHOD FOR PRODUCING THE SAME, LIGAND, COMPLEX, CATALYST AND METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL
  申请人：Ishihara Kazuaki

  公开号：US20100113786A1

  公开（公告）日：2010-05-06

  Disclosed is a method for highly efficiently obtaining an optically active alcohol from a carbonyl compound highly enantioselectively. Also disclosed is a ligand used in such a method. Specifically, an optically active alcohol is obtained by reacting a carbonyl compound and an organozinc compound by using a ligand (L) shown below.
• US8198445B2
  申请人：——

  公开号：US8198445B2

  公开（公告）日：2012-06-12
• US8624024B2
  申请人：——

  公开号：US8624024B2

  公开（公告）日：2014-01-07