2,3-Dimethyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole | 135718-50-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,3-Dimethyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole
• CAS: 135718-50-2
• 化学式: C₁₄H₁₄N₂S
• mdl: MFCD08815692
• 分子量: 242.345
• InChiKey: FGTAHWDOWDWKDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.214
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-4,5-二甲基噻唑 、 2-溴-4'-甲基苯乙酮 在 氢溴酸 作用下， 生成 2,3-Dimethyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole
  参考文献：
  名称：

  Synthesis and mitogenic activity of new imidazo[2,1-b]thiazoles

  摘要：

  Eight new imidazo[2,1-b]thiazoles were synthesized in order to evaluate their ability to stimulate the proliferation of thymic lymphocytes. The 2-chloro (5-8) proved more active than the 2,3-dimethyl derivatives (1-4): in particular compounds 6 and 7 were more active than levamisole.

  DOI：

  10.1016/0223-5234(91)90067-w

文献信息

• Synthesis and mitogenic activity of new imidazo[2,1-b]thiazoles
  作者：A Andreani、M Rambaldi、A Locatelli、AM Isetta

  DOI：10.1016/0223-5234(91)90067-w

  日期：1991.4

  Eight new imidazo[2,1-b]thiazoles were synthesized in order to evaluate their ability to stimulate the proliferation of thymic lymphocytes. The 2-chloro (5-8) proved more active than the 2,3-dimethyl derivatives (1-4): in particular compounds 6 and 7 were more active than levamisole.