2-(3-Ethylphenoxy)-5-(trifluoromethyl)pyridine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(3-Ethylphenoxy)-5-(trifluoromethyl)pyridine
• 化学式: C₁₄H₁₂F₃NO
• 分子量: 267.25
• InChiKey: ZDPQDUOLKFQWOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] INHIBITORS FOR SOLUBLE EPOXIDE HYDROLASE (SEH) AND FATTY ACID AMIDE HYDROLASE (FAAH)<br/>[FR] INHIBITEURS DE L'HYDROLASE D'ÉPOXYDE SOLUBLE (SEH) ET DE L'HYDROLASE D'AMIDE D'ACIDES GRAS (FAAH)
  申请人：UNIV CALIFORNIA

  公开号：WO2017160861A1

  公开（公告）日：2017-09-21

  The present invention provides compounds that are dual inhibitors of soluble epoxide hydrolase and fatty acid amide hydrolase. The present invention also provides methods of using the compounds to inhibit soluble epoxide hydrolase and fatty acid amide hydrolase, and to treat cancer.

  本发明提供了一种既能抑制可溶性环氧化物水解酶又能抑制脂肪酸酰胺水解酶的化合物。本发明还提供了使用这些化合物来抑制可溶性环氧化物水解酶和脂肪酸酰胺水解酶，并治疗癌症的方法。
• ALKYL PHENYL SULFIDE DERIVATIVE AND PEST CONTROL AGENT
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：US20150087833A1

  公开（公告）日：2015-03-26

  An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R 1 is, for example, a C 1 ˜C 6 alkyl group which is mono- or poly-substituted with halogen atom; R 2 is, for example, a halogen atom or a C 1 ˜C 6 alkyl group; R 3 is, for example, a hydrogen atom or a halogen atom; and R 4 is, for example, a hydrogen atom or a C 1 ˜C 12 alkyl group.] The derivative or the salt has an excellent pest control effect.

  一种由通式[I]表示的烷基苯基硫醚衍生物或其农业上可接受的盐，以及包含该衍生物或盐作为活性成分的农药。[在上述公式中，R1是例如一种C1〜C6烷基，其单个或多个取代为卤素原子; R2是例如卤素原子或C1〜C6烷基; R3是例如氢原子或卤素原子; R4是例如氢原子或C1〜C12烷基。]该衍生物或盐具有出色的杀虫效果。
• ALKYLPHENYLSULPHIDE DERIVATIVE AND PEST CONTROL AGENT
  申请人：Kumiai Chemical Industry Co., Ltd.

  公开号：EP2840078A1

  公开（公告）日：2015-02-25

  An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1∼C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1∼C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1∼C12 alkyl group.] The derivative or the salt has an excellent pest control effect.

  由通式[I]代表的烷基苯基硫醚衍生物或其农业上可接受的盐，以及含有该衍生物或盐作为活性成分的害虫防治剂。 [在上式中，R1 例如是由卤素原子单取代或多取代的 C1∼C6 烷基；R2 例如是卤素原子或 C1∼C6 烷基；R3 例如是氢原子或卤素原子；R4 例如是氢原子或 C1∼C12 烷基]。该衍生物或盐具有极佳的虫害防治效果。
• Alkyl phenyl sulfide derivative and pest control agent
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：US10023532B2

  公开（公告）日：2018-07-17

  An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1˜C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1˜C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1˜C12 alkyl group.] The derivative or the salt has an excellent pest control effect.

  由通式[I]代表的烷基苯基硫醚衍生物或其农业上可接受的盐，以及含有该衍生物或盐作为活性成分的害虫防治剂。 [在上式中，R1 例如是由卤素原子单取代或多取代的 C1˜C6烷基；R2 例如是卤素原子或 C1˜C6烷基；R3 例如是氢原子或卤素原子；R4 例如是氢原子或 C1˜C12烷基。］衍生物或盐具有极佳的虫害防治效果。
• Inhibitors for soluble epoxide hydrolase (SEH) and fatty acid amide hydrolase (FAAH)
  申请人：The Regents of the University of California

  公开号：US10858338B2

  公开（公告）日：2020-12-08

  The present invention provides compounds that are dual inhibitors of soluble epoxide hydrolase and fatty acid amide hydrolase. The present invention also provides methods of using the compounds to inhibit soluble epoxide hydrolase and fatty acid amide hydrolase, and to treat cancer.

  本发明提供的化合物是可溶性环氧化物水解酶和脂肪酸酰胺水解酶的双重抑制剂。本发明还提供了使用这些化合物抑制可溶性环氧化物水解酶和脂肪酸酰胺水解酶以及治疗癌症的方法。