(2'-acetyl-5'-chloro)-phenoxyacetic acid-methylester | 77956-83-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2'-acetyl-5'-chloro)-phenoxyacetic acid-methylester
• 英文别名: Methyl 2-(2-acetyl-5-chlorophenoxy)acetate
• CAS: 77956-83-3
• 化学式: C₁₁H₁₁ClO₄
• 分子量: 242.659
• InChiKey: RGALPZNIXYCVHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2'-acetyl-5'-chloro)-phenoxyacetic acid-methylester 在 sodium amide 作用下， 以 1,4-二氧六环 为溶剂， 反应 6.0h， 以30%的产率得到methyl 6-chloro-c-3-hydroxy-3-methyl-2,3-dihydro-r-2-benzofurancarboxylate
  参考文献：
  名称：

  Suzuki, Tsuneo; Tanemura, Kiyoshi; Horaguchi, Takaaki, Journal of Heterocyclic Chemistry, 1992, vol. 29, # 2, p. 423 - 429

  摘要：

  DOI：

文献信息

• KAUPMANN, W.;OHLENDORF, H. W.;WOLF, K. -U., EUR. J. MED. CHEM., 1985, 20, N 3, 207-212
  作者：KAUPMANN, W.、OHLENDORF, H. W.、WOLF, K. -U.

  DOI：——

  日期：——
• SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY
  申请人：SHIONOGI & CO., LTD.

  公开号：US20150158833A1

  公开（公告）日：2015-06-11

  The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.; a pharmaceutically acceptable salt or a hydrate thereof.
• US4279905A
  申请人：——

  公开号：US4279905A

  公开（公告）日：1981-07-21
• US4320061A
  申请人：——

  公开号：US4320061A

  公开（公告）日：1982-03-16
• US9440938B2
  申请人：——

  公开号：US9440938B2

  公开（公告）日：2016-09-13