manganese(II) acetate tetrahydrate | 110448-09-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: manganese(II) acetate tetrahydrate
• 英文别名: Manganese acetate tetrahydrate；manganese(2+);diacetate;tetrahydrate
• CAS: 110448-09-4
• 化学式: C₄H₁₄MnO₈
• 分子量: 245.088
• InChiKey: CESXSDZNZGSWSP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.79
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  84.3
• 氢给体数：
  4
• 氢受体数：
  8

ADMET

代谢

锰主要通过摄入被吸收，但也可以通过吸入。它在血浆中与α-2-巨球蛋白、白蛋白或转铁蛋白结合，并分布到大脑和所有其他哺乳动物组织，尽管它倾向于在肝脏、胰腺和肾脏中积累更多。锰能够存在于多种氧化状态，并且据信在体内会发生氧化状态的变化。锰的氧化状态可以影响组织的毒物动力学行为，甚至可能影响毒性。锰主要通过粪便排出。(L228)

Manganese is absorbed mainly via ingestion, but can also be inhaled. It binds to alpha-2-macroglobulin, albumin, or transferrin in the plasma and is distributed to the brain and all other mammalian tissues, though it tends to accumulate more in the liver, pancreas, and kidney. Manganese is capable of existing in a number of oxidation states and is believed to undergo changes in oxidation state within the body. Manganese oxidation state can influence tissue toxicokinetic behavior, and possibly toxicity. Manganese is excreted primarily in the faeces. (L228)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

锰是一种细胞毒素，可以损害运输系统、酶活性和受体功能。它主要针对中枢神经系统，尤其是基底神经节中的苍白球。人们认为，锰离子Mn(II)增强了各种胞内儿茶酚胺的自动氧化或转换，导致自由基、活性氧种和其他细胞毒性代谢产物的产生增加，同时耗尽细胞的抗氧化防御机制，导致氧化损伤和选择性地破坏多巴胺能神经元。除了多巴胺，还认为锰会干扰其他神经递质，如GABA和谷氨酸。为了产生氧化损伤，锰必须首先克服抗氧化酶超氧化物歧化酶。Mn(II)的神经毒性还与其在生理条件下替代Ca(II)的能力有关。它可以通过钙单转运体进入线粒体并抑制线粒体氧化磷酸化。它还可能抑制Ca(II)的外流，这可能导致线粒体膜完整性的丧失。Mn(II)已被证明能显著抑制线粒体顺乌头酸酶活性，改变氨基酸代谢和细胞铁稳态。(L228)

Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to perturbations other neurotransmitters, such as GABA and glutamate. In order to produce oxidative damage, manganese must first overwhelm the antioxidant enzyme manganese superoxide dismutase. The neurotoxicity of Mn(II) has also been linked to its ability to substitute for Ca(II) under physiological conditions. It can enter mitochondria via the calcium uniporter and inhibit mitochondrial oxidative phosphorylation. It may also inhibit the efflux of Ca(II), which can result in a loss of mitochondrial membrane integrity. Mn(II) has been shown to inhibit mitochondrial aconitase activity to a significant level, altering amino acid metabolism and cellular iron homeostasis. (L228)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类无致癌性（未列入国际癌症研究机构IARC清单）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

锰主要影响神经系统，可能导致行为改变和其他神经系统效应，包括动作可能变得缓慢和笨拙。这些症状足够严重时，被称为“锰中毒”。(L228)

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L228）；吸入（L228）

Oral (L228) ; inhalation (L228)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

锰主要影响神经系统，可能导致行为改变和其他神经系统效应，包括动作可能变得缓慢和笨拙。这种症状组合在足够严重时被称为“锰中毒”。

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

来源:Toxin and Toxin Target Database (T3DB)

反应信息

• 作为反应物：
  描述：

  2-(2-甲氧基乙氧基)乙酸 、 manganese(II) acetate tetrahydrate 以 甲苯 为溶剂， 反应 5.0h， 以99%的产率得到manganese(II) 2-(2-methoxyethoxy)acetate
  参考文献：
  名称：

  采用常压燃烧化学气相沉积工艺，用于金属氧化物薄膜沉积的钴和羧酸锰†

  摘要：

  通过相应的金属乙酸盐[ M ( OAc ) 2 ( H _ _ _ 2 O) 4 ] (M = Co, 1 ; M = Mn, 2 ) 和羧酸 HO 2 CCH 2 OC 2 H 4 OMe ( 3 )。IR 光谱证实了羧基配体与 M( II )的螯合或 μ-桥接结合模式。分子结构固态下的图5证实了 Mn( II ) 处的扭曲八面体排列，由两个羧基配体（包括它们的 α-醚氧原子）建立，从而形成一个整体的二维配位网络。用 TG-MS 研究了4和5的热分解行为，揭示了最初发生脱羧反应得到 [M(CH 2 OC 2 H 4 OMe) 2 ]，其进一步被 M-C、C-O 和 C-C 分解键断裂。配合物4和5用作 CCVD（燃烧化学气相沉积）前体，用于沉积 Co 3 O 4、结晶 Mn硅和玻璃基板上的3 O 4和非晶 Mn 2 O 3薄膜。使用三种不同的前体溶液（0.4、0.6 和 0.8 M）在 400

  DOI：

  10.1039/c8ra02288g
• 作为试剂：
  描述：

  2,5-二甲基硝基苯 、 、 氢溴酸 、 氧气 、 、 甲苯 、 溶剂黄146 在 cobalt(II) acetate tetrahydrate 、 manganese(II) acetate tetrahydrate 、 四氢化物钛 氧气 作用下， 以was formed in a 74 mole %的产率得到苯甲酸
  参考文献：
  名称：

  Process for catalytic oxidation of ortho-nitroaromatic compounds to

  摘要：

  公开了一种高产量生产邻硝基芳香酸的方法。该方法包括在惰性反应介质中，在共存存在可共氧化化合物、重金属催化剂和溴的情况下，将至少具有一个硝基邻位至少一个可氧化基团的邻硝基芳香化合物与分子氧反应。

  公开号：

  US04906771A1

文献信息

• Laser coding
  申请人：Khan Nazir

  公开号：US20050269304A1

  公开（公告）日：2005-12-08

  A method for marking an object, wherein the object comprises a material including a functional group and a metal compound or acid that causes an elimination reaction on irradiation with a laser, to form a reaction product of contrasting colour, comprises directing a laser beam on to the areas of the object to be marked For example, by using a carbohydrate and a metal salt, effective marking can be achieved on the coating of a pill or other edible material.

  一种标记物品的方法，其中物品包括含有功能基团和金属化合物或酸的材料，在激光照射下引起消除反应，形成对比色的反应产物。该方法包括将激光束直接照射到要标记的物品区域。例如，通过使用碳水化合物和金属盐，可以在药片或其他可食用材料的涂层上实现有效标记。
• Use Of Manganese Oxalates As Bleach Catalysts
  申请人：Reinhardt Gerd

  公开号：US20110166055A1

  公开（公告）日：2011-07-07

  The invention relates to the use of manganese oxalates in detergents and cleaning agents, in particular in cleaning agents containing peroxy compounds for hard surfaces.

  本发明涉及在洗涤剂和清洁剂中使用草酸锰，特别是在含有过氧化物化合物的硬表面清洁剂中使用。
• Use of manganese oxalates as bleach catalysts
  申请人：Reinhardt Gerd

  公开号：US08927478B2

  公开（公告）日：2015-01-06

  The invention relates to the use of manganese oxalates in detergents and cleaning agents, in particular in cleaning agents containing peroxy compounds for hard surfaces.

  本发明涉及在洗涤剂和清洁剂中使用草酸锰，特别是在含有过氧化物化合物的硬表面清洁剂中使用草酸锰。
• Synthesis and Crystal Structures of Octahedral Metal Complexes containing the New Dianion [PhP(Se,O)Se-Se(O,Se)PPh]2−
  作者：Weifeng Shi、Le Zhang、Maryam Shafaei-Fallah、Alexander Rothenberger

  DOI：10.1002/zaac.200600297

  日期：2007.3

  The synthesis and structures of three new compounds are reported. [Mg2PhP(Se,O)Se-Se(O,Se)PPh}2(thf)7(H2O)3] (1), [MgPhP(Se,O)Se-Se(O,Se)PPh}(thf)3(H2O)] (2), and [MnPhP(Se,O)Se-Se(O,Se)PPh}(thf)3(H2O)] (3) were prepared by treatment of Woollins' reagent [PhP(Se)(μ-Se)]2 with the corresponding hydrated metal acetates.

  报道了三种新化合物的合成和结构。[Mg2PhP(Se,O)Se-Se(O,Se)PPh}2(thf)7(H2O)3] (1), [MgPhP(Se,O)Se-Se(O,Se) PPh}(thf)3(H2O)] (2) 和 [MnPhP(Se,O)Se-Se(O,Se)PPh}(thf)3(H2O)] (3) Woollins 试剂 [PhP(Se)(μ-Se)]2 与相应的水合金属醋酸盐。
• Cobalt and manganese carboxylates for metal oxide thin film deposition by applying the atmospheric pressure combustion chemical vapour deposition process
  作者：B. S. M. Kretzschmar、K. Assim、A. Preuß、A. Heft、M. Korb、M. Pügner、T. Lampke、B. Grünler、H. Lang

  DOI：10.1039/c8ra02288g

  日期：——

  [M(CH2OC2H4OMe)2], which further decomposes by M–C, C–O and C–C bond cleavages. Complexes 4 and 5 were used as CCVD (combustion chemical vapour deposition) precursors for the deposition of Co3O4, crystalline Mn3O4 and amorphous Mn2O3 thin films on silicon and glass substrates. The deposition experiments were carried out using three different precursor solutions (0.4, 0.6 and 0.8 M) at 400 °C. Depending on the

  通过相应的金属乙酸盐[ M ( OAc ) 2 ( H _ _ _ 2 O) 4 ] (M = Co, 1 ; M = Mn, 2 ) 和羧酸 HO 2 CCH 2 OC 2 H 4 OMe ( 3 )。IR 光谱证实了羧基配体与 M( II )的螯合或 μ-桥接结合模式。分子结构固态下的图5证实了 Mn( II ) 处的扭曲八面体排列，由两个羧基配体（包括它们的 α-醚氧原子）建立，从而形成一个整体的二维配位网络。用 TG-MS 研究了4和5的热分解行为，揭示了最初发生脱羧反应得到 [M(CH 2 OC 2 H 4 OMe) 2 ]，其进一步被 M-C、C-O 和 C-C 分解键断裂。配合物4和5用作 CCVD（燃烧化学气相沉积）前体，用于沉积 Co 3 O 4、结晶 Mn硅和玻璃基板上的3 O 4和非晶 Mn 2 O 3薄膜。使用三种不同的前体溶液（0.4、0.6 和 0.8 M）在 400