(2E)-4-hydroxyhept-2-enal | 17427-22-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2E)-4-hydroxyhept-2-enal
• 英文别名: 4-hydroxy-hept-2t-enal；4-Hydroxyheptenal；(E)-4-hydroxyhept-2-enal
• CAS: 17427-22-4
• 化学式: C₇H₁₂O₂
• 分子量: 128.171
• InChiKey: AAIBHIYBGXKHAG-HWKANZROSA-N

物化性质

• 沸点：
  98-99 °C(Press: 2 Torr)
• 密度：
  0.964±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2E)-4-hydroxyhept-2-enal 以41%的产率得到2-正丙基呋喃
  参考文献：
  名称：

  (2E)-4-hydroxyalk-2-enals and 2-substituted furans as products of reactions of (2E)-4,4-dimethoxybut-2-enal with Grignard compounds

  摘要：

  Methods have been developed for the synthesis of (2E)-1,1-dimethoxyalk-2-en-4-ols and (2E)-4-hydroxyalk-2-enals by reaction of (2E)-4,4-dimethoxybut-2-enals and Grignard compounds. Thermal isomerization of (2E)-4-hydroxyalk-2-enals gave the corresponding 2-alkylfurans.

  DOI：

  10.1134/s1070428010030188
• 作为产物：
  描述：

  1,1-dimethoxy-hept-2t-ene 生成 (2E)-4-hydroxyhept-2-enal
  参考文献：
  名称：

  �ber die Wirkungen von Aldehyden auf gesunde und maligne Zellen, 2. Mitt.: Synthese von homologen 4-Hydroxy-2-alkenalen, I

  摘要：

  DOI：

  10.1007/bf01167149

文献信息

• Redox therapy for tumors
  申请人：——

  公开号：US20040018987A1

  公开（公告）日：2004-01-29

  The invention provides methods and compositions for treatment of tumors comprising administering to subject bearing a tumor an effective amount of at least one agent that decreases the [GSH] 2 /[GSSG] ratio in the malignant cells of said tumor, wherein said at least one agent is administered continuously to said patient for a period of time within the range of from about 15 to about 75 hours.

  本发明提供了治疗肿瘤的方法和组合物，包括向肿瘤患者施用有效量的至少一种降低[GSH&rsqb； 2 /[GSSG]在所述肿瘤的恶性细胞中的比率，其中所述至少一种制剂在约15至约75小时的范围内连续给所述患者施用一段时间。
• �ber die Wirkungen von Aldehyden auf gesunde und maligne Zellen, 3. Mitt.: Synthese von homologen 4-Hydroxy-2-alkenalen, II
  作者：H. Esterbauer、W. Weger

  DOI：10.1007/bf01167162

  日期：——
• KIT FOR TREATMENT OF CANCER
  申请人：Redoxia Israel Limited

  公开号：EP1755679A2

  公开（公告）日：2007-02-28
• Kit for Treatment of Cancer
  申请人：Hoffman Arnold

  公开号：US20080287541A1

  公开（公告）日：2008-11-20

  The present invention relates to a kit for the treatment of cancer comprising (a) a container for containing a first compound (i) or a precursor thereof, said first compound or precursor being a compound that oxidizes glutathione (GSH); (b) a container for containing a second compound (ii) or a precursor thereof, said second compound or precursor being a compound that forms an adduct or conjugate with GSH; (c) a container for containing a third compound (iii) or a precursor thereof, said third compound or precursor being a compound that inhibits the rate-limiting enzyme of GSH biosynthesis, gamma-glutamylcysteine synthetase (GCS); and (d) a container for containing a fourth compound (iv) or a precursor thereof, said fourth compound or precursor being a compound that inhibits the enzyme responsible for the conversion of GSSG to GSH, glutathione reductase (GR).
• US7858659B2
  申请人：——

  公开号：US7858659B2

  公开（公告）日：2010-12-28