morusin dimethyl ether | 62596-30-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: morusin dimethyl ether
• 英文别名: 2-(2,4-Dimethoxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
• CAS: 62596-30-9
• 化学式: C₂₇H₂₈O₆
• 分子量: 448.516
• InChiKey: CZSUZBXQIBWUGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  Morusin-trimethylaether 在 aluminum (III) chloride 作用下， 生成 morusin dimethyl ether
  参考文献：
  名称：

  The synthesis of morusin as a potent antitumor agent

  摘要：

  Morusin. which call be isolated from Chinese herbal medicine. is achieved in which the longest linear sequence is only 13 steps in 12% overall yield from commercially available phloroglucinol In addition, the metal/EtSH reagents for regioselective demethylation of polymethylated morusin were described Consequently this strategy provided a concise route 10 synthesize the morusin analogues as well Further biological studies of morusin. it exhibited strong antitumor effects with IC(50) similar to 3 0 mu M oil three cancel cells (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.002

文献信息

• The synthesis of morusin as a potent antitumor agent
  作者：Tsui-Hwa Tseng、Shien-Kai Chuang、Chao-Chin Hu、Chia-Fu Chang、Yu-Chao Huang、Cheng-Wei Lin、Yean-Jang Lee

  DOI：10.1016/j.tet.2009.12.002

  日期：2010.2

  Morusin. which call be isolated from Chinese herbal medicine. is achieved in which the longest linear sequence is only 13 steps in 12% overall yield from commercially available phloroglucinol In addition, the metal/EtSH reagents for regioselective demethylation of polymethylated morusin were described Consequently this strategy provided a concise route 10 synthesize the morusin analogues as well Further biological studies of morusin. it exhibited strong antitumor effects with IC(50) similar to 3 0 mu M oil three cancel cells (C) 2009 Elsevier Ltd All rights reserved