Pyridyl-4-methyl-pivalinsaeure-ester | 4810-76-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Pyridyl-4-methyl-pivalinsaeure-ester
• 英文别名: Pyridin-4-ylmethyl 2,2-dimethylpropanoate
• CAS: 4810-76-8
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: MIJJNHJDCJERAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Pyridyl-4-methyl-pivalinsaeure-ester 在 silver perchlorate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 8.0h， 生成 N-methyl picolinium trimethylacetate perchlorate
  参考文献：
  名称：

  C−O Bond Fragmentation of 4-Picolyl- and N-Methyl-4-picolinium Esters Triggered by Photochemical Electron Transfer

  摘要：

  Photochemical reduction of several 4-picolyl- and N-methyl-4-picolinium esters was examined using product analysis, laser flash photolysis, and fluorescence quenching. It is demonstrated that the radical (anions) formed in these reactions readily fragment to yield a carboxylic acid and a 4-pyridylmethyl radical intermediate. The high chemical and quantum yields observed for these photoreactions suggests that these esters can be used as photolabile protecting groups.

  DOI：

  10.1021/jo049501j
• 作为产物：
  描述：

  4-吡啶甲醇 、 三甲基乙酰氯 在 三乙胺 作用下， 以 苯 为溶剂， 反应 16.0h， 以82%的产率得到Pyridyl-4-methyl-pivalinsaeure-ester
  参考文献：
  名称：

  C−O Bond Fragmentation of 4-Picolyl- and N-Methyl-4-picolinium Esters Triggered by Photochemical Electron Transfer

  摘要：

  Photochemical reduction of several 4-picolyl- and N-methyl-4-picolinium esters was examined using product analysis, laser flash photolysis, and fluorescence quenching. It is demonstrated that the radical (anions) formed in these reactions readily fragment to yield a carboxylic acid and a 4-pyridylmethyl radical intermediate. The high chemical and quantum yields observed for these photoreactions suggests that these esters can be used as photolabile protecting groups.

  DOI：

  10.1021/jo049501j

文献信息

• Inhibitors of Histone Deacetylase
  申请人：Frechette Sylvie

  公开号：US20080227826A1

  公开（公告）日：2008-09-18

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions. One aspect of the invention provides compounds of formula (1): in which T, A and X are as described herein.

  这项发明涉及抑制组蛋白去乙酰化酶。该发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。该发明还提供了治疗细胞增殖性疾病和症状的组合物和方法。该发明的一个方面提供了式（1）的化合物：其中T、A和X如本文所述。
• Therapeutic compounds and uses thereof
  申请人：GENENTECH, INC.

  公开号：US10202378B2

  公开（公告）日：2019-02-12

  The present invention relates to compounds of formula (I): and to salts thereof, wherein R1-R6 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of TAF1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various TAF1-mediated disorders.

  本发明涉及式（I）化合物： 及其盐，其中 R1-R6 具有说明书中定义的任一值，以及其组合物和用途。这些化合物可用作 TAF1 的抑制剂。还包括包含式（I）化合物或其药学上可接受的盐的药物组合物，以及使用此类化合物和盐治疗各种TAF1介导的疾病的方法。
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：GENENTECH, INC.

  公开号：US20180009805A1

  公开（公告）日：2018-01-11

  The present invention relates to compounds of formula (I): and to salts thereof, wherein R 1 -R 6 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of TAF1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various TAF1-mediated disorders.
• US7645786B2
  申请人：——

  公开号：US7645786B2

  公开（公告）日：2010-01-12
• US8030344B2
  申请人：——

  公开号：US8030344B2

  公开（公告）日：2011-10-04