N-(3-acetylphenyl)-2-[(7-methoxy-4-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(3-acetylphenyl)-2-[(7-methoxy-4-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]acetamide
• 英文别名: N-(3-acetylphenyl)-2-[(7-methoxy-4-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide
• 化学式: C₂₂H₂₀N₄O₃S
• 分子量: 420.5
• InChiKey: YDQTWBQMVSTLRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHOD FOR DETERMINING SENSITIVITY OF TUMOR CELLS TO TYROSINE KINASE INHIBITOR AND COMPUTER PROGRAM PRODUCT
  申请人：KAWAI Masaaki

  公开号：US20110318768A1

  公开（公告）日：2011-12-29

  The present invention provides a method for determining sensitivity of the tumor cells to an EGFR and/or HER 2 inhibitor by evaluating inhibitory capacity of an Src inhibitor in a sample for measuring tyrosine kinase activity which is prepared from a biological sample containing tumor cells, a computer program and a method for determining effectiveness.

  本发明提供了一种方法，通过评估样本中Src抑制剂的抑制能力，测量来自含有肿瘤细胞的生物样本的酪氨酸激酶活性，以确定肿瘤细胞对EGFR和/或HER2抑制剂的敏感性，以及一种用于确定有效性的计算机程序和方法。
• METHOD FOR DETERMINING SENSITIVITY OF TUMOR CELLS TO DASATINIB AND COMPUTER PROGRAM
  申请人：KAWAI Masaaki

  公开号：US20130143236A1

  公开（公告）日：2013-06-06

  The present invention provides a method for determining sensitivity of tumor cells to dasatinib by evaluating inhibitory capacity of a predetermined tyrosine kinase inhibitor in a measurement sample which is prepared from a biological sample containing tumor cells and a computer program.