5-氧代-1-苯基-2-吡唑啉-3-甲酰胺 | 6401-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-氧代-1-苯基-2-吡唑啉-3-甲酰胺
• 英文名称: 3-Carbamoyl-1-phenyl-pyrazolon-(5)
• 英文别名: 5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acid amide；5-oxo-1-phenyl-2-pyrazoline-3-carboxamide；3-carbamoyl-1-phenyl-2-pyrazolin-5-one；1H-Pyrazole-3-carboxamide, 4,5-dihydro-5-oxo-1-phenyl-；5-oxo-1-phenyl-4H-pyrazole-3-carboxamide
• CAS: 6401-98-5
• 化学式: C₁₀H₉N₃O₂
• mdl: MFCD00210667
• 分子量: 203.2
• InChiKey: SPFXLCCBWAJCHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  75.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933199090

反应信息

• 作为反应物：
  描述：

  5-氧代-1-苯基-2-吡唑啉-3-甲酰胺 、 N-4,n-4-二乙基-2-甲基-1,4-苯二胺 在 sodium carbonate 、 silver(I) chloride 作用下， 生成 4-(4-diethylamino-2-methyl-phenylimino)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide
  参考文献：
  名称：

  Azomethine Dyes. I. Color and Constitution of Pyrazolone Azomethine Dyes

  摘要：

  DOI：

  10.1021/ja01147a011

文献信息

• METHOD OF PRODUCING A BISBENZODITHIOL COMPOUND
  申请人：Motoki Masuji

  公开号：US20090240067A1

  公开（公告）日：2009-09-24

  A method of producing a compound represented by formula (1), including: allowing 1,4-benzoquinone or 1,2-benzoquinone to react with a dithiocarbamate compound represented by formula (2) in a polar solvent: wherein R 1 and R 2 each independently represent a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group, R 1 and R 2 may be the same or different and may be combined with each other to form a ring, X represents an ion necessary to neutralize the charge of the molecule, m represents an integer of 1 to 2, n represents an integer of 1 to 2, M represents a hydrogen atom, a metal atom or a conjugate acid of a base, p represents an integer of 1 to 4, and q represents an integer of 1 to 4.

  一种生产由化学式（1）表示的化合物的方法，包括：允许1,4-苯醌或1,2-苯醌在极性溶剂中与由化学式（2）表示的二硫代氨基甲酸盐化合物发生反应：其中R1和R2各自独立地表示氢原子、烷基、芳基或杂环基，R1和R2可以相同也可以不同，并且可以结合在一起形成环，X表示中性化分子电荷所需的离子，m表示1至2的整数，n表示1至2的整数，M表示氢原子、金属原子或碱的共轭酸，p表示1至4的整数，q表示1至4的整数。
• Photographic silver halide materials containing dispersed
  申请人：Agfa-Gevaert, N.V.

  公开号：US04311787A1

  公开（公告）日：1982-01-19

  Light-sensitive photographic silver halide material comprising a hydrophilic colloid layer containing in dispersed state a light-absorbing merostyryl dye that corresponds to the following general formula: ##STR1## in which: R.sup.1 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, aralkyl or substituted aralkyl, R.sup.2 is carboxy, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, ureido, sulphamoyl or one of the groups represented by R.sup.1 ; at least one of R.sup.1 and R.sup.2 being or containing carboxy or carbamoyl, R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, and when R.sup.3 is alkyl or alkoxy it stands in ortho or para in respect of the hydroxy group, which itself is in ortho or para in respect of the methine group, said merostyryl dye containing no group that renders the dye soluble in the hydrophilic colloid layer.

  含有亲水性胶体层的感光银卤素材料，其中分散着一种与以下通式相对应的吸光的美洛菲染料： ##STR1## 其中：R.sup.1是氢、烷基、取代烷基、芳基、取代芳基、芳基烷基或取代芳基烷基，R.sup.2是羧基、烷氧羰基、芳基氧羰基、氨基甲酰、脲基、磺酰胺或由R.sup.1表示的其中一种基团；R.sup.1和R.sup.2中至少有一个是或包含羧基或氨基甲酰基团，R.sup.3是氢、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基，当R.sup.3是烷基或烷氧基时，它与羟基团相对，而羟基团本身与亚甲基团相对，所述美洛菲染料不含使染料在亲水性胶体层中溶解的基团。
• Pyrazole-amides and -sulfonamides
  申请人：Atkinson N. Robert

  公开号：US20050049237A1

  公开（公告）日：2005-03-03

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

  本发明提供了一种通过抑制电压依赖性钠通道中的钠离子流来治疗疾病的化合物、组合物和方法。更具体地，本发明提供了吡唑酰胺和磺酰胺，以及其组合物和方法，这些化合物、组合物和方法对于治疗中枢或外周神经系统疾病特别是疼痛和慢性疼痛非常有用，通过阻止与所述疾病的发作或复发有关的钠通道。本发明的化合物、组合物和方法特别适用于通过抑制包括PN3亚基的通道中的离子流来治疗神经病理性或炎性疼痛。
• PYRAZOLE-AMIDES AND -SULFONAMIDES
  申请人：Atkinson N. Robert

  公开号：US20080064690A1

  公开（公告）日：2008-03-13

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

  本发明提供了一种通过抑制电压依赖性钠通道中的钠离子通量来治疗疾病的化合物、组合物和方法。更具体地，本发明提供了嘧唑酰胺和磺酰胺、组合物和方法，用于治疗中枢或外周神经系统障碍，特别是疼痛和慢性疼痛，通过阻断与指示条件的发生或复发有关的钠通道。本发明的化合物、组合物和方法特别适用于通过抑制包括PN3亚单位的通道中的离子通量来治疗神经病理性或炎症性疼痛。
• Photographic silver halide materials containing dispersed light-absorbing merostyryl dyes
  申请人：AGFA-GEVAERT naamloze vennootschap

  公开号：EP0021513A1

  公开（公告）日：1981-01-07

  Light-sensitive photographic silver halide material comprising a hydrophilic colloid layer containing in dispersed state a light-absorbing merostyryl dye that corresponds to the following general formula: in which: R1 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, aralkyl or substituted aralkyl, R2 is carboxy, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, ureido, sulphamoyl or one of the groups represented by R1; at least one of R' and R2 being or containing carboxy or carbamoyl, R3 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, and when R3 is alkyl or alkoxy it stands in ortho or para in respect of the hydroxy group, which itself is in ortho or para in respect of the methine group, said merostyryl dye containing no group that renders the dye soluble in the hydrophilic colloid layer.

  感光照相卤化银材料，包括亲水性胶体层，该胶体层在分散状态下含有符合以下通式的吸光美洛斯基染料： 其中 R1 是氢、烷基、取代烷基、芳基、取代芳基、烷基或取代烷基、 R2 是羧基、烷氧羰基、芳氧羰基、氨基甲酰基、脲基、氨基磺酰基或 R1 所代表的基团之一； R' 和 R2 中至少有一个是或含有羧基或氨基甲酰基、 R3 是氢、C1-C4 烷基、C1-C4 烷氧基，当 R3 是烷基或烷氧基时，它与羟基为正交或对位，而羟基本身与甲 基为正交或对位、 所述美拉西丁基染料不含使染料溶于亲水胶体层的基团。