[5-Amino-3-(4-methylphenyl)imidazol-4-yl]-(4-bromophenyl)methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [5-Amino-3-(4-methylphenyl)imidazol-4-yl]-(4-bromophenyl)methanone
• 化学式: C₁₇H₁₄BrN₃O
• 分子量: 356.2
• InChiKey: GQZNESZOBQKYAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MYOGENESIS ACCELERATOR, AMYOTROPHY SUPPRESSOR, MEDICINAL COMPOSITION, AND TAZ ACTIVATOR
  申请人：National University Corporation Tokyo Medical and Dental University

  公开号：EP3103455A1

  公开（公告）日：2016-12-14

  The invention provides a novel myogenesis promotor, a novel muscle atrophy inhibitor, a novel composition or a novel TAZ activator. The myogenesis promotor, the muscle atrophy inhibitor,the composition and the TAZ activator include a composition represented by the following Formula (I) as an active ingredient. In Formula (I), R1 represents a hydrogen atom or an alkyl group; R2 represents an aryl group, a heterocyclic group, an alkyl group or the like; R3 represents -NR5R6 or -N=C-R7; each of R5 and R6 independently represents a hydrogen atom, an alkyl group or the like; R7 represents -NR10R11, an aryl group or a heterocyclic group; R8 represents a hydrogen atom, an alkyl group or the like; R9 represents a hydrogen atom, an alkyl group or the like; each of R10 and R11 independently represents a hydrogen atom, an alkyl group or the like; R4 represents a cyano group or -C(=O)R12; and R12 represents an aryl group, a heterocyclic group, an alkyl group or the like.

  本发明提供了一种新型肌生成促进剂、一种新型肌肉萎缩抑制剂、一种新型组合物或一种新型 TAZ 激活剂。肌生成促进剂、肌肉萎缩抑制剂、组合物和 TAZ 激活剂包括由下式（I）代表的组合物作为活性成分。式（I）中，R1 代表氢原子或烷基；R2 代表芳基、杂环基、烷基或类似物；R3 代表 -NR5R6 或 -N=C-R7；R5 和 R6 各自独立地代表氢原子、烷基或类似物；R7 代表 -NR10R11、芳基或杂环基；R8 代表氢原子、烷基或类似物； R9 代表氢原子、烷基或类似物； R10 和 R11 各自独立地代表氢原子、烷基或类似物； R4 代表氰基或 -C(=O)R12；以及 R12 代表芳基、杂环基、烷基或类似物。
• Myogenesis Promotor, Muscle Atrophy Inhibitor, Medical Composition and Taz Activator
  申请人：NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

  公开号：US20160346251A1

  公开（公告）日：2016-12-01

  The invention provides a novel myogenesis promotor, a novel muscle atrophy inhibitor, a novel composition or a novel TAZ activator. The myogenesis promotor, the muscle atrophy inhibitor, the composition and the TAZ activator include a composition represented by the following Formula (I) as an active ingredient. In Formula (I), R 1 represents a hydrogen atom or an alkyl group; R 2 represents an aryl group, a heterocyclic group, an alkyl group or the like; R 3 represents —NR 5 R 6 or —N═C—R 7 ; each of R 5 and R 6 independently represents a hydrogen atom, an alkyl group or the like; R 7 represents —NR 10 R 11 , an aryl group or a heterocyclic group; R 8 represents a hydrogen atom, an alkyl group or the like; R 9 represents a hydrogen atom, an alkyl group or the like; each of R 10 and R 11 independently represents a hydrogen atom, an alkyl group or the like; R 4 represents a cyano group or —C(═O)R 12 ; and R 12 represents an aryl group, a heterocyclic group, an alkyl group or the like.