(Z,Z)-1,1'-[1,2-ethanediylbis(oxy)]bis-9-octadecene | 17367-13-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z,Z)-1,1'-[1,2-ethanediylbis(oxy)]bis-9-octadecene
• 英文别名: Dioleylethandiol；1,2-bis-(2-octadec-9c-enyloxy)-ethane；1,1'-ethane-1,2-diyldioxy-bis-octadec-9c-ene；Ethane, 1,2-bis(9-octadecenyloxy)-, (Z,Z)-；(Z)-1-[2-[(Z)-octadec-9-enoxy]ethoxy]octadec-9-ene
• CAS: 17367-13-4
• 化学式: C₃₈H₇₄O₂
• 分子量: 563.004
• InChiKey: HLSUQUJDDMLNMX-CLFAGFIQSA-N

物化性质

• 沸点：
  613.0±48.0 °C(Predicted)
• 密度：
  0.858±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  15.7
• 重原子数：
  40
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
  申请人：Panzner Steffen

  公开号：US20080089932A1

  公开（公告）日：2008-04-17

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种由混合脂质组成的两性脂质体，所述混合物包括阳离子型两性分子、阴离子型两性分子和可选的一种或多种中性两性分子，其中至少一种阳离子型和阴离子型两性分子可被电荷化，所述阳离子型和阴离子型两性分子的相应量被选择为在第一个较低的pH下具有过量的正电荷的阳离子型两性分子，在第二个较高的pH下具有过量的负电荷的阴离子型两性分子，且所述混合物具有介于第一个和第二个pH之间的等电点；其特征在于所述的阳离子型和阴离子型两性分子适合在所述等电点处彼此形成脂质盐。还公开了预测给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• Amphoteric Liposomes, A Method Of Formulating An Amphoteric Liposome And A Method Of Loading An Amphoteric Liposome
  申请人：Panzner Steffen

  公开号：US20120135065A1

  公开（公告）日：2012-05-31

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种两性脂质体，由混合脂质组成，所述混合物包括阳离子两性分子、阴离子两性分子和可选的一个或多个中性两性分子，其中至少一种阳离子和阴离子两性分子是可带电的，并且所述阳离子和阴离子两性分子的相应量被选择为在第一个较低的pH值下存在过量的带正电荷的阳离子两性分子，在第二个较高的pH值下存在过量的带负电荷的阴离子两性分子，并且所述混合物具有介于第一个和第二个pH值之间的等电点；其特征在于所述带正电荷的阳离子和带负电荷的阴离子两性分子被适应在所述等电点处彼此形成脂质盐。还公开了预测在给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• AMPHOTERIC LIPOSOME FORMULATIONS
  申请人：Marina Biotech, Inc.

  公开号：US20160151282A1

  公开（公告）日：2016-06-02

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  由混合脂质组成的两性脂质体，所述混合物包括阳离子两性分子、阴离子两性分子和可选的一种或多种中性两性分子，其中至少一种阳离子和阴离子两性分子可被带电，并且所述阳离子和阴离子两性分子的相应量被选择为在第一个较低pH下存在过量的带正电的阳离子两性分子，在第二个较高pH下存在过量的带负电的阴离子两性分子，并且所述混合物具有介于第一个和第二个pH之间的等电点；其特征在于所述带正电的阳离子和带负电的阴离子两性分子被适应在所述等电点处彼此形成脂质盐。还公开了预测给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• Magnetic recording tape
  申请人：The B.F. GOODRICH Company

  公开号：EP0122567A1

  公开（公告）日：1984-10-24

  Magnetic recording tape comprising a fiexibie substrate with magnetic particles secured to the substrate by means of a binder comprising a reaction product of a desccyanate with a blend of a chain extender and a hydroxylzerminated polycarbonate, said binder having high tensiis stength is hydrolytically stable, and is soluble in selected commercial solvents.

  磁性记录带，包括一个含磁性颗粒的基板，磁性颗粒通过粘合剂固定在基板上，粘合剂包括脱氰酸酯与扩链剂和羟基erminated聚碳酸酯混合物的反应产物。
• Radiation curable thermoplastic polyurethanes
  申请人：THE B.F. GOODRICH COMPANY

  公开号：EP0422500A2

  公开（公告）日：1991-04-17

  Radiation curable linear thermoplastic polyurethanes having imido pendent groups of the formula (A) wherein Z is an unsaturated C₂₋₁₂ hydrocarbyl or substituted hydrocarbyl group (preferably H₃CC=CCH₃) capable of undergoing photocrosslinking with another like group Z, are prepared by reaction of (a) a macroglycol of molecular weight 500-7,000, (b) one or more glycol chain extenders each having a molecular weight less than 500, which may include one or more low molecular weight aliphatic glycols (e.g., a C₂₋₁₂ alkylene glycol or mixture thereof), and (c) an organic diisocyanate. Either a macroglycol or a chain extender must include a radiation sensitive pendent imido group of the above formula (A). The thermo­plastic polyurethanes herein have hard and soft segments. Pendent groups (A) are present in the hard segments when a chain extender containing pendent group (A) is used, and are present in the soft segment when a macroglycol having pendent group (A) is used. The thermoplastic polyurethanes are useful for various purposes including coatings and magnetic recording media. Radiation curing gives a thermoset polyurethane having high hardness and good solvent resistance.

  可辐射固化的线型热塑性聚氨酯，具有式 (A) 的亚氨基垂基 其中 Z 是不饱和 C₂₋₁₂烃基或取代的烃基（最好是 H₃CC=CCH₃），能与另一个类似基团 Z 发生光交联、通过以下反应制备：(a) 分子量为 500-7,000 的大分子二醇；(b) 一种或多种二醇扩链剂，每种扩链剂的分子量均小于 500，其中可包括一种或多种低分子量脂肪族二醇（如：H.g.,C₂₋₁₂ 烷二醇或其混合物），以及 (c) 有机二异氰酸酯。无论是大环二醇还是扩链剂，都必须包括上式 (A) 的辐射敏感的悬垂亚氨基。此处的热塑性聚氨酯具有硬段和软段。当使用含有悬垂基团（A）的扩链剂时，悬垂基团（A）存在于硬段中；当使用具有悬垂基团（A）的多元醇时，悬垂基团（A）存在于软段中。热塑性聚氨酯可用于各种用途，包括涂料和磁性记录介质。辐射固化产生的热固性聚氨酯具有高硬度和良好的耐溶剂性。