9-[m-(hydroxymethyl)phenyl]adenine | 469887-26-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 9-[m-(hydroxymethyl)phenyl]adenine
• 英文别名: [3-(6-Aminopurin-9-yl)phenyl]methanol
• CAS: 469887-26-1
• 化学式: C₁₂H₁₁N₅O
• 分子量: 241.252
• InChiKey: YLLAKSAQDGIJRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  9-[m-(hydroxymethyl)phenyl]adenine 在 disodium hydrogenphosphate 、 adenosine deaminase 作用下， 反应 6.0h， 以100%的产率得到9-[m-(hydroxymethyl)phenyl]hypoxanthine
  参考文献：
  名称：

  9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase

  摘要：

  New phenyl adenine compounds 5-7 were synthesized as analogues of adenosine and studied for their adenosine deaminase (ADA) substrate activity. The 9-[(o-hydroxymethyl)phenyl]methyl]adenine 5 and 9-[(m-hydroxymethyl)phenyl]adenine 7 were deaminated by ADA, and 9-[(o-hydroxyethyl)phenyl]adenine 6 was not deaminated up to 7 days. The ADA substrates 5 and 7 were deaminated quantitatively to their inosine analogues in 10 and 6 h, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00192-0
• 作为产物：
  描述：

  6-chloro-9-[3-(hydroxymethyl)phenyl]purine 在 氨 作用下， 以 甲醇 为溶剂， 生成 9-[m-(hydroxymethyl)phenyl]adenine
  参考文献：
  名称：

  9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase

  摘要：

  New phenyl adenine compounds 5-7 were synthesized as analogues of adenosine and studied for their adenosine deaminase (ADA) substrate activity. The 9-[(o-hydroxymethyl)phenyl]methyl]adenine 5 and 9-[(m-hydroxymethyl)phenyl]adenine 7 were deaminated by ADA, and 9-[(o-hydroxyethyl)phenyl]adenine 6 was not deaminated up to 7 days. The ADA substrates 5 and 7 were deaminated quantitatively to their inosine analogues in 10 and 6 h, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00192-0

文献信息

• 9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase
  作者：Mohamed Brakta、Devangachinta Murthy、L'Ouverture Ellis、Shashikant Phadtare

  DOI：10.1016/s0960-894x(02)00192-0

  日期：2002.6

  New phenyl adenine compounds 5-7 were synthesized as analogues of adenosine and studied for their adenosine deaminase (ADA) substrate activity. The 9-[(o-hydroxymethyl)phenyl]methyl]adenine 5 and 9-[(m-hydroxymethyl)phenyl]adenine 7 were deaminated by ADA, and 9-[(o-hydroxyethyl)phenyl]adenine 6 was not deaminated up to 7 days. The ADA substrates 5 and 7 were deaminated quantitatively to their inosine analogues in 10 and 6 h, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.