[(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]hexan-2-yl] benzoate | 412960-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]hexan-2-yl] benzoate
• CAS: 412960-87-3
• 化学式: C₂₅H₄₃NO₅Si
• 分子量: 465.706
• InChiKey: FRJOLYZYIOFLCE-SFTDATJTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.17
• 重原子数：
  32
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]hexan-2-yl] benzoate 在 吡啶 、 氢氟酸 、 caesium carbonate 作用下， 以 甲醇 、 乙腈 为溶剂， 生成 (R)-1-[(S)-1-(tert-butoxycarbonylamino)-3-methylbutyl]oxirane
  参考文献：
  名称：

  Synthesis of statine employing a general syn-amino alcohol building block

  摘要：

  An orthogonally protected syn-2-amino-1,3,4-butanetriol has been employed as a general syn-amino alcohol building block in the synthesis of statine. This synthesis demonstrates the utility of the building block in the synthesis of any syn-amino alcohol compound. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02206-7
• 作为产物：
  描述：

  [(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-4-(4-methylphenyl)sulfonyloxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]butan-2-yl] benzoate 在 copper(I) bromide dimethylsulfide complex 、 sodium hydride 作用下， 生成 [(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]hexan-2-yl] benzoate
  参考文献：
  名称：

  Synthesis of statine employing a general syn-amino alcohol building block

  摘要：

  An orthogonally protected syn-2-amino-1,3,4-butanetriol has been employed as a general syn-amino alcohol building block in the synthesis of statine. This synthesis demonstrates the utility of the building block in the synthesis of any syn-amino alcohol compound. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02206-7

文献信息

• Synthesis of statine employing a general syn-amino alcohol building block
  作者：Soon Ji Kwon、Soo Y Ko

  DOI：10.1016/s0040-4039(01)02206-7

  日期：2002.1

  An orthogonally protected syn-2-amino-1,3,4-butanetriol has been employed as a general syn-amino alcohol building block in the synthesis of statine. This synthesis demonstrates the utility of the building block in the synthesis of any syn-amino alcohol compound. (C) 2002 Elsevier Science Ltd. All rights reserved.