[(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-4-(4-methylphenyl)sulfonyloxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]butan-2-yl] benzoate | 412960-85-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-4-(4-methylphenyl)sulfonyloxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]butan-2-yl] benzoate
• CAS: 412960-85-1
• 化学式: C₂₉H₄₃NO₈SSi
• 分子量: 593.814
• InChiKey: VPCXFHVVISUGOV-DQEYMECFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.84
• 重原子数：
  40
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  [(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-4-(4-methylphenyl)sulfonyloxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]butan-2-yl] benzoate 在 copper(I) bromide dimethylsulfide complex 、 sodium hydride 作用下， 生成 [(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]hexan-2-yl] benzoate
  参考文献：
  名称：

  Synthesis of statine employing a general syn-amino alcohol building block

  摘要：

  An orthogonally protected syn-2-amino-1,3,4-butanetriol has been employed as a general syn-amino alcohol building block in the synthesis of statine. This synthesis demonstrates the utility of the building block in the synthesis of any syn-amino alcohol compound. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02206-7
• 作为产物：
  描述：

  (2S,3R)-O(1)-benzyl-N(2)-(tert-butoxycarbonyl)-O(3)-benzoyl-O(4)-(tert-butyldimethylsilyl)-2-amino-1,3,4-butanetriol 在 palladium on activated charcoal 吡啶 、 氢气 作用下， 生成 [(2R,3S)-1-[tert-butyl(dimethyl)silyl]oxy-4-(4-methylphenyl)sulfonyloxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]butan-2-yl] benzoate
  参考文献：
  名称：

  Synthesis of statine employing a general syn-amino alcohol building block

  摘要：

  An orthogonally protected syn-2-amino-1,3,4-butanetriol has been employed as a general syn-amino alcohol building block in the synthesis of statine. This synthesis demonstrates the utility of the building block in the synthesis of any syn-amino alcohol compound. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02206-7