5-氯-1,3-二甲基吡唑-4-胺 | 100674-51-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 中文名称: 5-氯-1,3-二甲基吡唑-4-胺
• 英文名称: 5-chloro-1,3-dimethyl-pyrazol-4-amine
• 英文别名: 5-chloro-1,3-dimethyl-1H-pyrazol-4-ylamine；4-Amino-5-chloro-1,3-dimethylpyrazole；5-chloro-1,3-dimethyl-1H-pyrazol-4-amine；5-chloro-1,3-dimethylpyrazol-4-amine
• CAS: 100674-51-9
• 化学式: C₅H₈ClN₃
• mdl: MFCD19206032
• 分子量: 145.592
• InChiKey: WLXPOBMZOSWCKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-(4-cyanophenoxy)phenyl)acetic acid 、 2-氯-1-甲基吡啶碘化物 、 5-氯-1,3-二甲基吡唑-4-胺 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以52%的产率得到5-chloro-4-(4-(4-cyanophenoxy) phenylacetoamino)-1,3-dimethylpyrazole
  参考文献：
  名称：

  EP1319657

  摘要：

  公开号：
• 作为产物：
  描述：

  5-氯-1,3-二甲基-4-硝基-1H-吡唑 在 溶剂黄146 、 锌 作用下， 以 四氢呋喃 为溶剂， 以53%的产率得到5-氯-1,3-二甲基吡唑-4-胺
  参考文献：
  名称：

  [EN] (5,6-DIHYDRO)PYRIMIDO[4,5-E]INDOLIZINES
  [FR] (5,6-DIHYDRO)PYRIMIDO[4,5-E]INDOZILINES

  摘要：

  本发明涉及一种公式(I)的化合物，其中R1和R2独立地选自包括可选择性取代的（6-10C）芳基和（1-5C）杂芳基基团在内的组。这些化合物可用于药物组合物中，特别是在癌症治疗中。

  公开号：

  WO2015155042A1

文献信息

• N-(4-PYRAZOLYL)AMIDE DERIVATIVES, CHEMICALS FOR AGRICULTURAL AND HORTICULTURAL USE, AND USAGE OF THE SAME
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：EP1319657A1

  公开（公告）日：2003-06-18

  N-(4-Pyrazolyl)amide derivatives of the general formula (I), exhibiting excellent control activities as bacteriocides, fungicides, insecticides, or nematicides for agricultural and horticultural use; chemicals for agricultural and horticultural use; and usage of the same, wherein R1 is H, optionally halogenated (C1-C6)alkyl, optionally substituted phenylsulfonyl, optionally substituted phenyl, or the like; R2 and R3 are each H, halogeno, CN, NO2, OH, SH, NH2, optionally halogenated (C1-C6)alkyl, optionally substituted phenyl, or the like; R4 is H, optionally halogenated (C1-C6)alkyl, cyano(C1-C6)alkyl, optionally substituted phenyl(C1-C6)alkyl, or the like; R5 is a group of formula (a) or (b), optionally substituted naphthyl, or the like; and Y is (C1-C6)alkylene, optionally halogenated (C1-C6)alkyl(C1-C6)alkyl(C1-C6)alkylene, or the like.

  通式(I)的 N-(4-吡唑基)酰胺衍生物、 其中 R1 是 H、任选卤代（C1-C6）烷基、任选取代的苯磺酰基、任选取代的苯基或类似物；R2和R3各自是H、卤代、CN、NO2、OH、SH、NH2、任选卤代的(C1-C6)烷基、任选取代的苯基或类似物；R4是H、任选卤代的(C1-C6)烷基、氰基(C1-C6)烷基、任选取代的苯基(C1-C6)烷基或类似物；R5是式(a)或(b)的基团、任选取代的萘基或类似物；Y是(C1-C6)亚烷基、任选卤代的(C1-C6)烷基(C1-C6)烷基或类似物。
• (5,6-DIHYDRO)PYRIMIDO[4,5-E]INDOLIZINES
  申请人：Netherlands Translational Research Center B.V.

  公开号：EP3129374A1

  公开（公告）日：2017-02-15
• N-(4-pyrazolyl) amide derivatives, chemicals for agricultural and horticultural use, and usage of the same
  申请人：——

  公开号：US20040043904A1

  公开（公告）日：2004-03-04

  N-(4-Pyrazolyl)amide derivatives of the general formula (I), 1 exhibiting excellent control activities as bacteriocides, fungicides, insecticides, or nematicides for agricultural and horticultural use; chemicals for agricultural and horticultural use; and usage of the same, wherein R 1 is H, optionally halogenated (C 1 -C 6 )alkyl, optionally substituted phenylsulfonyl, optionally substituted phenyl, or the like; R 2 and R 3 are each H, halogeno, CN, NO 2 , OH, SH, NH 2 , optionally halogenated (C 1 -C 6 )alkyl, optionally substituted phenyl, or the like; R 4 is H, optionally halogenated (C 1 -C 6 )alkyl, cyano(C 1 -C 6 )alkyl, optionally substituted phenyl(C 1 -C 6 )alkyl, or the like; R 5 is a group of formula (a) or (b), optionally substituted naphthyl, or the like; and Y is (C 1 -C 6 )alkylene, optionally halogenated (C 1 -C 6 )alkyl(C 1 -C 6 )alkyl(C 1 -C 6 )alkylene, or the like.
• NOVEL HALOGEN-SUBSTITUTED COMPOUNDS
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20170217899A1

  公开（公告）日：2017-08-03

  The invention relates inter alia to halogen-substituted compounds of the general formula (I) in which the substituents A 1 , R 1 -R 3 and Z 1 -Z 3 have the meanings given in the description. Also described are processes for preparing the compounds of the formula (I) and possible intermediates for the preparation of these compounds. The compounds according to the invention are particularly suitable for controlling insects, arachnids and nematodes in agriculture and ectoparasites in veterinary medicine.
• US9856258B2
  申请人：——

  公开号：US9856258B2

  公开（公告）日：2018-01-02