3-Chloro-2-[(4-methoxyphenyl)methyl]-5-(trifluoromethyl)pyridine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-Chloro-2-[(4-methoxyphenyl)methyl]-5-(trifluoromethyl)pyridine
• 化学式: C₁₄H₁₁ClF₃NO
• 分子量: 301.696
• InChiKey: VCZBEOFVMCBSAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-氟苯基硼酸 、 3-Chloro-2-[(4-methoxyphenyl)methyl]-5-(trifluoromethyl)pyridine 在 dihydrogen dichloro-bis(di-tert-butylphosphinito-κP)palladium(2-) caesium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 以94%的产率得到3-(3-Fluorophenyl)-2-[(4-methoxyphenyl)methyl]-5-(trifluoromethyl)pyridine
  参考文献：
  名称：

  Use of highly reactive, versatile and air-stable palladium–phosphinous acid complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a catalyst for the optimized Suzuki–Miyaura cross-coupling of less reactive heteroaryl chlorides and arylboronic acids

  摘要：

  Using highly reactive air-stable palladium-phosphinous acid complex [(t-Bu)(2)P(OH)](2)PdCl2 (POPd) as a catalyst, synthesis of heteroaryl-aryl cross-coupled products via palladium-catalyzed Suzuki-Miyaura coupling of less reactive substituted 3-chloropyridines with arylboronic acids was achieved in high yields. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.05.010

文献信息

• Use of highly reactive, versatile and air-stable palladium–phosphinous acid complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a catalyst for the optimized Suzuki–Miyaura cross-coupling of less reactive heteroaryl chlorides and arylboronic acids
  作者：Subhash P. Khanapure、David S. Garvey

  DOI：10.1016/j.tetlet.2004.05.010

  日期：2004.6

  Using highly reactive air-stable palladium-phosphinous acid complex [(t-Bu)(2)P(OH)](2)PdCl2 (POPd) as a catalyst, synthesis of heteroaryl-aryl cross-coupled products via palladium-catalyzed Suzuki-Miyaura coupling of less reactive substituted 3-chloropyridines with arylboronic acids was achieved in high yields. (C) 2004 Elsevier Ltd. All rights reserved.